Dictyostelium cytokinesis: From molecules to mechanics

Douglas Robinson, Kristine D. Girard, Edelyn Octtaviani, Elizabeth M. Reichl

Research output: Contribution to journalArticle


Cytokinesis is the mechanical process that allows the simplest unit of life, the cell, to divide, propagating itself. To divide, the cell converts chemical energy into mechanical energy to produce force. This process is thought to be active, due in large part to the mechanochemistry of the myosin-II ATPase. The cell's viscoelasticity defines the context and perhaps the magnitude of the forces that are required for cytokinesis. The viscoelasticity may also guide the force-generating apparatus, specifying the cell shape change that results. Genetic, biochemical, and mechanical measurements are providing a quantitative view of how real proteins control this essential life process.

Original languageEnglish (US)
Pages (from-to)719-727
Number of pages9
JournalJournal of Muscle Research and Cell Motility
Issue number7-8
StatePublished - 2002


ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology

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