TY - JOUR
T1 - Dictyostelium cytokinesis
T2 - From molecules to mechanics
AU - Robinson, Douglas N.
AU - Girard, Kristine D.
AU - Octtaviani, Edelyn
AU - Reichl, Elizabeth M.
N1 - Funding Information:
This work was supported by the Burroughs Wellcome Fund (DNR) and the Johns Hopkins School of Medicine BCMB training grant (EMR).
PY - 2002
Y1 - 2002
N2 - Cytokinesis is the mechanical process that allows the simplest unit of life, the cell, to divide, propagating itself. To divide, the cell converts chemical energy into mechanical energy to produce force. This process is thought to be active, due in large part to the mechanochemistry of the myosin-II ATPase. The cell's viscoelasticity defines the context and perhaps the magnitude of the forces that are required for cytokinesis. The viscoelasticity may also guide the force-generating apparatus, specifying the cell shape change that results. Genetic, biochemical, and mechanical measurements are providing a quantitative view of how real proteins control this essential life process.
AB - Cytokinesis is the mechanical process that allows the simplest unit of life, the cell, to divide, propagating itself. To divide, the cell converts chemical energy into mechanical energy to produce force. This process is thought to be active, due in large part to the mechanochemistry of the myosin-II ATPase. The cell's viscoelasticity defines the context and perhaps the magnitude of the forces that are required for cytokinesis. The viscoelasticity may also guide the force-generating apparatus, specifying the cell shape change that results. Genetic, biochemical, and mechanical measurements are providing a quantitative view of how real proteins control this essential life process.
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U2 - 10.1023/A:1024419510314
DO - 10.1023/A:1024419510314
M3 - Review article
C2 - 12952070
AN - SCOPUS:0042009272
SN - 0142-4319
VL - 23
SP - 719
EP - 727
JO - Journal of Muscle Research and Cell Motility
JF - Journal of Muscle Research and Cell Motility
IS - 7-8
ER -