Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate: Its Role in Regulation of Cat Brain Extracellular Fluid

Bizhan Aarabi, Mel H. Epstein, Donlin M. Long

Research output: Contribution to journalArticlepeer-review

Abstract

The role of dibutyryl cyclic adenosine 3′,5′-monophosphate (db cAMP) in influencing the water content of the cat's gray and white matter was evaluated by intracortical injection of 20 μL of 2 × 10-1 to 2 × 10-6M solution of db cAMP. Cholera toxin, a stimulator of adenylate cyclase, also was tested. Concentrations of db cAMP less than 10-3M failed to produce significant change in brain water content, while concentrations greater than 10-2M produced 31.5% ± 8% and 17.3% ± 3.6% increases in white matter volume, respectively (P γ.05). Cholera toxin did not increase brain water levels. These results are discussed in relation to the pathophysiology of brain edema.

Original languageEnglish (US)
Pages (from-to)498-500
Number of pages3
JournalArchives of neurology
Volume36
Issue number8
DOIs
StatePublished - Aug 1979

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Dibutyryl Cyclic Adenosine 3′,5′-Monophosphate: Its Role in Regulation of Cat Brain Extracellular Fluid'. Together they form a unique fingerprint.

Cite this