Diazepam infusion in tetanus: Correlation of drug levels with effect

Joseph R. Dasta, Kenneth L. Brier, Gregory A. Kidwell, Steven Schonfeld, Daniel Couri

Research output: Contribution to journalArticle

Abstract

A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalSouthern Medical Journal
Volume74
Issue number3
StatePublished - 1981
Externally publishedYes

Fingerprint

Tetanus
Diazepam
Pharmaceutical Preparations
Muscle Rigidity
Spasm
Guidelines
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dasta, J. R., Brier, K. L., Kidwell, G. A., Schonfeld, S., & Couri, D. (1981). Diazepam infusion in tetanus: Correlation of drug levels with effect. Southern Medical Journal, 74(3), 278-280.

Diazepam infusion in tetanus : Correlation of drug levels with effect. / Dasta, Joseph R.; Brier, Kenneth L.; Kidwell, Gregory A.; Schonfeld, Steven; Couri, Daniel.

In: Southern Medical Journal, Vol. 74, No. 3, 1981, p. 278-280.

Research output: Contribution to journalArticle

Dasta, JR, Brier, KL, Kidwell, GA, Schonfeld, S & Couri, D 1981, 'Diazepam infusion in tetanus: Correlation of drug levels with effect', Southern Medical Journal, vol. 74, no. 3, pp. 278-280.
Dasta, Joseph R. ; Brier, Kenneth L. ; Kidwell, Gregory A. ; Schonfeld, Steven ; Couri, Daniel. / Diazepam infusion in tetanus : Correlation of drug levels with effect. In: Southern Medical Journal. 1981 ; Vol. 74, No. 3. pp. 278-280.
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