Diazepam infusion in tetanus: Correlation of drug levels with effect

Joseph R. Dasta, Kenneth L. Brier, Gregory A. Kidwell, Steven A. Schonfeld, Daniel Couri

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalSouthern medical journal
Volume74
Issue number3
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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