Diazepam infusion in tetanus: Correlation of drug levels with effect

Joseph R. Dasta; Kenneth L. Brier; Gregory A. Kidwell; Steven A. Schonfeld; Daniel Couri

doi:10.1097/00007611-198103000-00006

Diazepam infusion in tetanus: Correlation of drug levels with effect

Joseph R. Dasta, Kenneth L. Brier, Gregory A. Kidwell, Steven A. Schonfeld, Daniel Couri

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.

Original language	English (US)
Pages (from-to)	278-280
Number of pages	3
Journal	Southern medical journal
Volume	74
Issue number	3
DOIs	https://doi.org/10.1097/00007611-198103000-00006
State	Published - Mar 1981
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1097/00007611-198103000-00006

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title = "Diazepam infusion in tetanus: Correlation of drug levels with effect",

abstract = "A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.",

author = "Dasta, {Joseph R.} and Brier, {Kenneth L.} and Kidwell, {Gregory A.} and Schonfeld, {Steven A.} and Daniel Couri",

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AU - Schonfeld, Steven A.

AU - Couri, Daniel

PY - 1981/3

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AB - A patient with muscle spasms and rigidity associated with tetanus was successfully treated with a continuous infusion of diazepam. This beneficial response was associated with a minimal serum diazepam concentration of 500 ng/ml. The major metabolite of diazepam, DMD, did not appear to exert substantial activity. Guidelines for dosing diazepam are provided.

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Diazepam infusion in tetanus: Correlation of drug levels with effect

Abstract

ASJC Scopus subject areas

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