Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheets

Hiroshi Ashikaga, James W. Covell, Jeffrey H. Omens

Research output: Contribution to journalArticle

Abstract

Diastolic dysfunction in volume-overload hypertrophy by aortocaval fistula is characterized by increased passive stiffness of the left ventricle (LV). We hypothesized that changes in passive properties are associated with abnormal myolaminar sheet mechanics during diastolic filling. We determined three-dimensional finite deformation of myofiber and myolaminar sheets in the LV free wall of six dogs with cineradiography of implanted markers during development of volume-overload hypertrophy by aortocaval fistula. After 9 ± 2 wk of volume overload, all dogs developed edema of extremities, pulmonary congestion, elevated LV end-diastolic pressure (5 ± 2 vs. 21 ± 4 mmHg, P <0.05), and increased LV volume. There was no significant change in systolic function [dP/dtmax: 2,476 ± 203 vs. 2,330 ± 216 mmHg/s, P = not significant (NS)]. Diastolic relaxation was significantly reduced (dP/ dtmin: -2,466 ± 190 vs. -2,076 ± 166 mmHg/s, P <0.05; time constant of LV pressure decline: 32 ± 2 vs. 43 ± 1 ms, P <0.05), whereas duration of diastolic filling was unchanged (304 ± 33 vs. 244 ± 42 ms, P = NS). Fiber stretch and sheet shear occur predominantly in the first third of diastolic filling, and chronic volume overload induced remodeling in lengthening of the fiber and reorientation of the laminar sheet architecture. Sheet shear was significantly increased and delayed at the subendocardial layer (P <0.05), whereas magnitude of fiber stretch was not altered in volume overload (P = NS). These findings indicate that enhanced filling in volume-overload hypertrophy is achieved by enhanced sheet shear early in diastole. These results provide the first evidence that changes in motion of radially oriented laminar sheets may play an important functional role in pathology of diastolic dysfunction in this model.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume288
Issue number6 57-6
DOIs
StatePublished - Jun 2005

Fingerprint

Hypertrophy
Heart Ventricles
Fistula
Cineradiography
Dogs
Diastole
Pulmonary Edema
Mechanics
Extremities
Pathology
Blood Pressure
Pressure

Keywords

  • Diastolic function
  • Fiber
  • Finite deformation
  • Sheet
  • Strain

ASJC Scopus subject areas

  • Physiology

Cite this

Diastolic dysfunction in volume-overload hypertrophy is associated with abnormal shearing of myolaminar sheets. / Ashikaga, Hiroshi; Covell, James W.; Omens, Jeffrey H.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 288, No. 6 57-6, 06.2005.

Research output: Contribution to journalArticle

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