Diagnostic yield of peripheral lymph node needle-core biopsies in HIV-infected adults with suspected smear-negative tuberculosis

D. Wilson, J. B. Nachega, R. E. Chaisson, G. Maartens

Research output: Contribution to journalArticle

Abstract

Significant lymphadenopathy in human immunodeficiency virus (HIV) infected adults in developing countries is usually caused by tuberculosis. We studied the safety and diagnostic yield of needle-core biopsies, under local anaesthetic, of enlarged lymph nodes in 26 HIV-infected adults presenting with suspected tuberculosis who were sputum smear-negative. Biopsy samples were sent for histology and mycobacterial culture. Induced sputum, urine and blood were also sent for mycobacterial culture. The procedure was well tolerated. A definitive diagnosis was made on initial needle-core biopsy in 22 subjects (85%) and in two of three subjects who underwent a second needle-core biopsy. Tuberculosis was the final diagnosis in 24 subjects (92%).

Original languageEnglish (US)
Pages (from-to)220-222
Number of pages3
JournalInternational Journal of Tuberculosis and Lung Disease
Volume9
Issue number2
StatePublished - Feb 1 2005

Keywords

  • Africa
  • HIV infection
  • Lymph node
  • Needle biopsy
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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