Diagnostic utility of cardiac biomarkers in discriminating takotsubo cardiomyopathy from acute myocardial infarction

Mandeep Singh Randhawa, Ashwat Singh Dhillon, Harris C. Taylor, Zhiyuan Sun, Milind Y. Desai

Research output: Contribution to journalArticlepeer-review

Abstract

Background Takotsubo cardiomyopathy (TC) mimics acute myocardial infarction (AMI). We postulated that ventricular dysfunction in TC in the absence of significant myocardial necrosis would produce higher B-type natriuretic peptide (BNP)/troponin T (TnT) and BNP/creatine kinase MB fraction (CKMB) ratios than in AMI. Methods and Results We studied 58 consecutive TC (age 65.8 ± 82.9) and 97 AMI patients (age 59.8 ± 83.4). The ratios of BNP/TnT and BNP/CKMB were calculated with the use of first simultaneously drawn laboratory values. Receiver operating characteristic curves were used to distinguish TC from AMI with 95% specificity based on cardiac biomarker ratios. Median BNP/TnT and BNP/CKMB ratios were, respectively, 1,292 [interquartile range 443.4-2,657.9] and 28.44 [13.7-94.8] in the TC group and 226.9 [69.91-426.32] and 3.63 [1.07-10.02] in the AMI group (P

Original languageEnglish (US)
Pages (from-to)2-8
Number of pages7
JournalJournal of Cardiac Failure
Volume20
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • cardiac biomarkers
  • electrocardiogram and acute myocardial infarction
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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