Diagnostic utility of cardiac biomarkers in discriminating takotsubo cardiomyopathy from acute myocardial infarction

Mandeep Singh Randhawa, Ashwat Singh Dhillon, Harris C. Taylor, Zhiyuan Sun, Milind Y. Desai

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Background Takotsubo cardiomyopathy (TC) mimics acute myocardial infarction (AMI). We postulated that ventricular dysfunction in TC in the absence of significant myocardial necrosis would produce higher B-type natriuretic peptide (BNP)/troponin T (TnT) and BNP/creatine kinase MB fraction (CKMB) ratios than in AMI. Methods and Results We studied 58 consecutive TC (age 65.8 ± 82.9) and 97 AMI patients (age 59.8 ± 83.4). The ratios of BNP/TnT and BNP/CKMB were calculated with the use of first simultaneously drawn laboratory values. Receiver operating characteristic curves were used to distinguish TC from AMI with 95% specificity based on cardiac biomarker ratios. Median BNP/TnT and BNP/CKMB ratios were, respectively, 1,292 [interquartile range 443.4-2,657.9] and 28.44 [13.7-94.8] in the TC group and 226.9 [69.91-426.32] and 3.63 [1.07-10.02] in the AMI group (P

Original languageEnglish (US)
Pages (from-to)2-8
Number of pages7
JournalJournal of Cardiac Failure
Volume20
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • cardiac biomarkers
  • electrocardiogram and acute myocardial infarction
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Diagnostic utility of cardiac biomarkers in discriminating takotsubo cardiomyopathy from acute myocardial infarction'. Together they form a unique fingerprint.

Cite this