Diagnostic tests in ragweed-allergic asthma. A comparison of direct skin tests, leukocyte histamine release, and quantitative bronchial challenge

C. Allen Bruce, Richard R Rosenthal, Lawrence M. Lichtenstein, Philip S. Norman

Research output: Contribution to journalArticle


Thirty-six patients with a history of seasonal ragweed asthma were tested. Direct intradermal skin tests, leukocyte histamine release, and quantitative inhalation bronchial challenge correlated significantly. Data reported suggest that quantitative skin tests are as diagnostically valuable as quantitative inhalation bronchial challenge or leukocyte histamine release. Data also suggest that lung and skin mast cells and circulating basophils respond as a single population of cells to ragweed antigens.

Original languageEnglish (US)
Pages (from-to)230-239
Number of pages10
JournalThe Journal of Allergy and Clinical Immunology
Issue number4
Publication statusPublished - 1974


ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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