@article{5771851cce3144b3aec085c887dc4745,
title = "Diagnostic potential of tumor DNA from ovarian cyst fluid",
abstract = "We determined whether the mutations found in ovarian cancers could be identified in the patients{\textquoteright} ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non- neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.",
author = "Yuxuan Wang and Karin Sundfeldt and Constantina Mateoiu and Shih, {Ie Ming} and Kurman, {Robert J.} and Joy Schaefer and Natalie Silliman and Isaac Kinde and Simeon Springer and Michael Foote and Bj{\"o}rg Kristjansdottir and Nathan James and Kinzler, {Kenneth W.} and Nickolas Papadopoulos and Diaz, {Luis A.} and Bert Vogelstein",
note = "Funding Information: Virginia and D.K. Ludwig Fund for Cancer Research Bert Vogelstein Banyan Gate Foundation Bert Vogelstein Sol Goldman Sequencing Facility at Johns Hopkins Bert Vogelstein National Institutes of Health CA43460 Bert Vogelstein Cancerfonden 10-0699 Karin Sundfeldt BioCARE Program at the University of Gothenburg 9/14-15 Karin Sundfeldt Access to Learning Fund LUA/ALF Grant 70950 Karin Sundfeldt WeCanCureCancer Karin Sundfeldt The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Wang et al.",
year = "2016",
month = jul,
day = "15",
doi = "10.7554/eLife.15175",
language = "English (US)",
volume = "5",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
number = "2016JULY",
}