Diagnostic Potential of Extracellular MicroRNA in Respiratory Diseases

Dhamotharan Pattarayan, Rajesh K. Thimmulappa, Vilwanathan Ravikumar, Subbiah Rajasekaran

Research output: Contribution to journalArticle

Abstract

Lack of markers of subclinical disease state and clinical phenotype other than pulmonary function test has made the diagnosis and interventions of environmental respiratory diseases a major challenge. MicroRNAs (miRNAs), small non-coding single stranded RNAs, have emerged as potential disease-modifier in various environmental respiratory diseases. They can also be found in various body fluids and are remarkably stable. Because of their high stability, disease-specific expression, and the ease to detect and quantify them have raised the potential of miRNAs in body fluids to be useful clinical diagnostic biomarkers for lung disease phenotyping. In the present review, we provide a comprehensive overview of progress made in identifying miRNAs in various body fluids including blood, serum, plasma, bronchoalveolar lavage (BAL) fluid, and sputum as biomarkers for a wide range of human respiratory diseases such as acute lung injury/acute respiratory distress syndrome (ALI/ARDS), idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and asthma. Finally, we discuss several challenges remain to be concerned and suggest few disease-specific and non-specific miRNAs to become part of future clinical practice.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalClinical Reviews in Allergy and Immunology
DOIs
StateAccepted/In press - Sep 27 2016
Externally publishedYes

Keywords

  • Biological fluids
  • Biomarker
  • Extracellular miRNA
  • Lung diseases
  • MicroRNAs

ASJC Scopus subject areas

  • Immunology and Allergy

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