Diagnostic point-of-care tests in resource-limited settings

Paul K. Drain, Emily P. Hyle, Farzad Noubary, Kenneth A. Freedberg, Douglas Wilson, William Ramses Bishai, William Rodriguez, Ingrid V. Bassett

Research output: Contribution to journalArticle

Abstract

The aim of diagnostic point-of-care testing is to minimise the time to obtain a test result, thereby allowing clinicians and patients to make a quick clinical decision. Because point-of-care tests are used in resource-limited settings, the benefits need to outweigh the costs. To optimise point-of-care testing in resource-limited settings, diagnostic tests need rigorous assessments focused on relevant clinical outcomes and operational costs, which differ from assessments of conventional diagnostic tests. We reviewed published studies on point-of-care testing in resource-limited settings, and found no clearly defined metric for the clinical usefulness of point-of-care testing. Therefore, we propose a framework for the assessment of point-of-care tests, and suggest and define the term test efficacy to describe the ability of a diagnostic test to support a clinical decision within its operational context. We also propose revised criteria for an ideal diagnostic point-of-care test in resource-limited settings. Through systematic assessments, comparisons between centralised testing and novel point-of-care technologies can be more formalised, and health officials can better establish which point-of-care technologies represent valuable additions to their clinical programmes.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalLancet Infectious Diseases
Volume14
Issue number3
DOIs
StatePublished - Mar 2014

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Point-of-Care Systems
Routine Diagnostic Tests
Clinical Decision Support Systems
Costs and Cost Analysis
Needs Assessment
Point-of-Care Testing
Health

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., ... Bassett, I. V. (2014). Diagnostic point-of-care tests in resource-limited settings. Lancet Infectious Diseases, 14(3), 239-249. https://doi.org/10.1016/S1473-3099(13)70250-0

Diagnostic point-of-care tests in resource-limited settings. / Drain, Paul K.; Hyle, Emily P.; Noubary, Farzad; Freedberg, Kenneth A.; Wilson, Douglas; Bishai, William Ramses; Rodriguez, William; Bassett, Ingrid V.

In: Lancet Infectious Diseases, Vol. 14, No. 3, 03.2014, p. 239-249.

Research output: Contribution to journalArticle

Drain, PK, Hyle, EP, Noubary, F, Freedberg, KA, Wilson, D, Bishai, WR, Rodriguez, W & Bassett, IV 2014, 'Diagnostic point-of-care tests in resource-limited settings', Lancet Infectious Diseases, vol. 14, no. 3, pp. 239-249. https://doi.org/10.1016/S1473-3099(13)70250-0
Drain, Paul K. ; Hyle, Emily P. ; Noubary, Farzad ; Freedberg, Kenneth A. ; Wilson, Douglas ; Bishai, William Ramses ; Rodriguez, William ; Bassett, Ingrid V. / Diagnostic point-of-care tests in resource-limited settings. In: Lancet Infectious Diseases. 2014 ; Vol. 14, No. 3. pp. 239-249.
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