Diagnostic performance of placental alpha-microglobulin-1 test in women with prolonged pre-labour rupture of membranes

George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Lydia Ijeoma Eleje, Joseph Ifeanyichukwu Ikechebelu, Evaristus Anthony Afiadigwe, Frank O. Ezugwu, Gerald Okanandu Udigwe, Charles I. Okafor, Chukwuemeka Okwudili Ezeama

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Objectives: To determine diagnostic performance of placental alpha-microglobulin-1 (PAMG-1) test compared to conventional clinical assessment (CCA) in women with prolonged pre-labour rupture of membranes (PROM).Methods: A double-blind study of women with symptoms and signs of PROM in Nnamdi Azikiwe University Teaching Hospital, Nnewi and University of Nigeria Teaching Hospital, Enugu, in south-east Nigeria using CCA for PROM and PAMG-1 test was done. Women were included if their symptoms, signs or complaints suggestive of PROM was more than 24 h duration. PROM was diagnosed if two out of three methods from CCA (pooling, positive nitrazine test or ferning) were present. Confirmation of PROM was done after delivery using any two of these clinical criteria: delivery in 48 h to 7 days, evidence of chorioamnionitis, membranes obviously ruptured at delivery and adverse perinatal outcomes strongly correlated with prolonged PROM.Results: Accuracy, specificity and sensitivity value for CCA were 72.5, 36.8 and 86.0% lower than for PAMG-1 test which were 95.7, 94.1 and 96.2%. In equivocal cases, PAMG-1 was significantly more accurate than CCA (92.3% versus 38.5%; p < 0.001).Conclusions: This study in women with prolonged PROM, confirms that PAMG-1 test has high diagnostic accuracy irrespective of the duration of PROM before clinical evaluation.

Original languageEnglish (US)
Pages (from-to)1291-1296
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number8
StatePublished - Apr 17 2016
Externally publishedYes


  • Accuracy
  • PAMG-1
  • conventional clinical assessment
  • prolonged rupture of membranes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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