Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: Design and implementation of the CORE320 multicenter, multinational diagnostic study

Andrea L. Vavere, Gregory G. Simon, Richard T. George, Carlos E. Rochitte, Andrew E. Arai, Julie M Miller, Marcello Di Carli, Armin Zadeh, Marc Dewey, Hiroyuki Niinuma, Roger Laham, Frank J. Rybicki, Joanne D. Schuijf, Narinder Paul, John Hoe, Sachio Kuribyashi, Hajime Sakuma, Cesar Nomura, Tan Swee Yaw, Klaus F. KofoedKunihiro Yoshioka, Melvin E. Clouse, Jeffrey A Brinker, Christopher Cox, Joao Lima

Research output: Contribution to journalArticle

Abstract

Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study (" Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography" ). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.

Original languageEnglish (US)
Pages (from-to)370-381
Number of pages12
JournalJournal of Cardiovascular Computed Tomography
Volume5
Issue number6
DOIs
Publication statusPublished - Nov 2011

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Keywords

  • Computed tomography
  • Coronary angiography
  • Multicenter study
  • Myocardial perfusion imaging
  • Study design and implementation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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