Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study

Richard George, Armin Arbab-Zadeh, Rodrigo J. Cerci, Andrea L. Vavere, Kakuya Kitagawa, Marc Dewey, Carlos E. Rochitte, Andrew E. Arai, Narinder Paul, Frank J. Rybicki, Albert C. Lardo, Melvin E. Clouse, Joao A.C. Lima

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. Coronary MDCT angiography has been shown to be an accurate noninvasive tool for the diagnosis of obstructive coronary artery disease (CAD). Its sensitivity and negative predictive value for diagnosing percentage of stenosis are unsurpassed compared with those of other noninvasive testing methods. However, in its current form, it provides no information regarding the physiologic impact of CAD and is a poor predictor of myocardial ischemia. CORE320 is a multicenter multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SPECT myocardial perfusion imaging. CONCLUSION. We aim to describe the CT acquisition, reconstruction, and analysis methods of the CORE320 study.

Original languageEnglish (US)
Pages (from-to)829-837
Number of pages9
JournalAmerican Journal of Roentgenology
Volume197
Issue number4
DOIs
StatePublished - Oct 1 2011

Keywords

  • Coronary CT angiography
  • Coronary atherosclerosis
  • Myocardial CT perfusion imaging
  • Myocardial ischemia
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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