Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study

Richard T. George; Armin Arbab-Zadeh; Rodrigo J. Cerci; Andrea L. Vavere; Kakuya Kitagawa; Marc Dewey; Carlos E. Rochitte; Andrew E. Arai; Narinder Paul; Frank J. Rybicki; Albert C. Lardo; Melvin E. Clouse; Joao A.C. Lima

doi:10.2214/AJR.10.5689

Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study

Richard T. George, Armin Arbab-Zadeh, Rodrigo J. Cerci, Andrea L. Vavere, Kakuya Kitagawa, Marc Dewey, Carlos E. Rochitte, Andrew E. Arai, Narinder Paul, Frank J. Rybicki, Albert C. Lardo, Melvin E. Clouse, Joao A.C. Lima

School of Medicine

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

OBJECTIVE. Coronary MDCT angiography has been shown to be an accurate noninvasive tool for the diagnosis of obstructive coronary artery disease (CAD). Its sensitivity and negative predictive value for diagnosing percentage of stenosis are unsurpassed compared with those of other noninvasive testing methods. However, in its current form, it provides no information regarding the physiologic impact of CAD and is a poor predictor of myocardial ischemia. CORE320 is a multicenter multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SPECT myocardial perfusion imaging. CONCLUSION. We aim to describe the CT acquisition, reconstruction, and analysis methods of the CORE320 study.

Original language	English (US)
Pages (from-to)	829-837
Number of pages	9
Journal	American Journal of Roentgenology
Volume	197
Issue number	4
DOIs	https://doi.org/10.2214/AJR.10.5689
State	Published - Oct 2011

Keywords

Coronary CT angiography
Coronary atherosclerosis
Myocardial CT perfusion imaging
Myocardial ischemia
SPECT

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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George, R. T., Arbab-Zadeh, A., Cerci, R. J., Vavere, A. L., Kitagawa, K., Dewey, M., Rochitte, C. E., Arai, A. E., Paul, N., Rybicki, F. J., Lardo, A. C., Clouse, M. E., & Lima, J. A. C. (2011). Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study. American Journal of Roentgenology, 197(4), 829-837. https://doi.org/10.2214/AJR.10.5689

Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study. / George, Richard T.; Arbab-Zadeh, Armin; Cerci, Rodrigo J. et al.
In: American Journal of Roentgenology, Vol. 197, No. 4, 10.2011, p. 829-837.

Research output: Contribution to journal › Article › peer-review

George, RT, Arbab-Zadeh, A, Cerci, RJ, Vavere, AL, Kitagawa, K, Dewey, M, Rochitte, CE, Arai, AE, Paul, N, Rybicki, FJ, Lardo, AC, Clouse, ME & Lima, JAC 2011, 'Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study', American Journal of Roentgenology, vol. 197, no. 4, pp. 829-837. https://doi.org/10.2214/AJR.10.5689

George RT, Arbab-Zadeh A, Cerci RJ, Vavere AL, Kitagawa K, Dewey M et al. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study. American Journal of Roentgenology. 2011 Oct;197(4):829-837. doi: 10.2214/AJR.10.5689

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title = "Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study",

abstract = "OBJECTIVE. Coronary MDCT angiography has been shown to be an accurate noninvasive tool for the diagnosis of obstructive coronary artery disease (CAD). Its sensitivity and negative predictive value for diagnosing percentage of stenosis are unsurpassed compared with those of other noninvasive testing methods. However, in its current form, it provides no information regarding the physiologic impact of CAD and is a poor predictor of myocardial ischemia. CORE320 is a multicenter multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SPECT myocardial perfusion imaging. CONCLUSION. We aim to describe the CT acquisition, reconstruction, and analysis methods of the CORE320 study.",

keywords = "Coronary CT angiography, Coronary atherosclerosis, Myocardial CT perfusion imaging, Myocardial ischemia, SPECT",

author = "George, {Richard T.} and Armin Arbab-Zadeh and Cerci, {Rodrigo J.} and Vavere, {Andrea L.} and Kakuya Kitagawa and Marc Dewey and Rochitte, {Carlos E.} and Arai, {Andrew E.} and Narinder Paul and Rybicki, {Frank J.} and Lardo, {Albert C.} and Clouse, {Melvin E.} and Lima, {Joao A.C.}",

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AU - Cerci, Rodrigo J.

AU - Vavere, Andrea L.

AU - Kitagawa, Kakuya

AU - Dewey, Marc

AU - Rochitte, Carlos E.

AU - Arai, Andrew E.

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AU - Lardo, Albert C.

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AB - OBJECTIVE. Coronary MDCT angiography has been shown to be an accurate noninvasive tool for the diagnosis of obstructive coronary artery disease (CAD). Its sensitivity and negative predictive value for diagnosing percentage of stenosis are unsurpassed compared with those of other noninvasive testing methods. However, in its current form, it provides no information regarding the physiologic impact of CAD and is a poor predictor of myocardial ischemia. CORE320 is a multicenter multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SPECT myocardial perfusion imaging. CONCLUSION. We aim to describe the CT acquisition, reconstruction, and analysis methods of the CORE320 study.

KW - Coronary CT angiography

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KW - Myocardial CT perfusion imaging

KW - Myocardial ischemia

KW - SPECT

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Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320-MDCT: The CT angiography and perfusion methods of the CORE320 multicenter multinational diagnostic study

Abstract

Keywords

ASJC Scopus subject areas

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