Diagnostic evaluation of food-related allergic diseases

John Eckman; Sarbjit S. Saini; Robert G. Hamilton

doi:10.1186/1710-1492-5-2

Diagnostic evaluation of food-related allergic diseases

John Eckman, Sarbjit S. Saini, Robert G. Hamilton

School of Medicine

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Food allergy is a serious and potentially life-threatening problem for an estimated 6% of children and 3.7% of adults. This review examines the diagnostic process that begins with a patient's history and physical examination. If the suspicion of IgE-mediated food allergy is compelling based on the history, skin and serology tests are routinely performed to provide confirmation for the presence of food-specific IgE antibody. In selected cases, a provocation challenge may be required as a definitive or gold standard reference test for confirmation of IgE mediated reactions to food. Variables that influence the accuracy of each of the diagnostic algorithm phases are discussed. The clinical significance of food allergen-specific IgE antibody cross-reactivity and IgE antibody epitope mapping of food allergens is overviewed. The advantages and limitations of the various diagnostic procedures are examined with an emphasis on future trends in technology and reagents.

Original language	English (US)
Article number	2
Journal	Allergy, Asthma and Clinical Immunology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1186/1710-1492-5-2
State	Published - Oct 22 2009

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Pulmonary and Respiratory Medicine

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10.1186/1710-1492-5-2

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AB - Food allergy is a serious and potentially life-threatening problem for an estimated 6% of children and 3.7% of adults. This review examines the diagnostic process that begins with a patient's history and physical examination. If the suspicion of IgE-mediated food allergy is compelling based on the history, skin and serology tests are routinely performed to provide confirmation for the presence of food-specific IgE antibody. In selected cases, a provocation challenge may be required as a definitive or gold standard reference test for confirmation of IgE mediated reactions to food. Variables that influence the accuracy of each of the diagnostic algorithm phases are discussed. The clinical significance of food allergen-specific IgE antibody cross-reactivity and IgE antibody epitope mapping of food allergens is overviewed. The advantages and limitations of the various diagnostic procedures are examined with an emphasis on future trends in technology and reagents.

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Diagnostic evaluation of food-related allergic diseases

Abstract

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