TY - JOUR
T1 - Diagnostic criteria of limited adenocarcinoma of the prostate on needle biopsy
AU - Epstein, Jonathan I.
N1 - Funding Information:
Over a period of 25 weeks 434 needle biopsy specimens of the prostate were sent to the author for consultation because of diagnostic concerns. The final diagnoses were cancer (69%), benign (13%), atypical but not diagnostic (10 % ), high grade prostatic intraepithelial neoplasia (PIN) (5%), and miscellaneous (3%). The most common benign entities mimicking cancer were atrophy (29 specimens) and adenosis (19 specimens). The 300 cancer specimens were analyzed further. Architecturally, the presence of small glands between larger benign glands was the most common pattern seen in 80% of carcinomas; haphazard growth patterns, single cells, and cribriform glands were seen less frequently. The following diagnostic features were helpful: nuclear enlargement (77% of specimens); prominent nucleoll (76%); pink acellular intraluminal secretions (53%); amphophilic cytoplasm (39%); blue-tinged mucinous secretions (34%); crystalloids (25%); PIN (13%); mitotic figures (11%); and perineural invasion (3%). The mean and median numbers of malignant glands in this series were 31 and 20, respectively (range, two to 300). Tumors In recent years there has been an explosive increase in needle biopsies of the prostate. The reasons for this phenomenon are multifactorial. First, an increasing number of needle biopsies are being performed as a consequence of screening for prostate cancer using tests for serum prostate-specific antigen. Transrectal ultrasound also has resulted in a greater number of radiologically visible lesions from which biopsy specimens are taken. Another reason for the increase in prostate biopsies is the use of the thin biopsy needle, which allows a greater number of biopsies to be performed with less morbidity. Finally, urologists are more willing to do prostate biopsies because of improvements in therapy; once a diagnosis of cancer is made, refinements in radical prostatectomy techniques have resulted in treatment options with more tolerable morbidity. As a result of the dramatic increase in the number of needle biopsies being done, pathologists are confronted with an ever increasing number of small prostate biopsy specimens in which the diagnosis often is difficult. To date, the majority of works dealing with the diagnosis of cancer on needle biopsy have been in books, book chapters, or review articles. The current study was undertaken to more rigorously categorize the diagnostic criteria for limited cancer on needle biopsy From The Johns Hopkins Medical Institutions, Baltimore, MD. Accepted for publication June 28, 1994. Supported in part by a National Institutes of Health SPORE grant for prostate cancer. Address correspondence and reprint requests to Jonathan I. Epstein, MD, Department of Pathology, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21285. Copyright © 1995 by W.B. Saunders Company 0046-8177/95/2602-001455.00/0 with a Gleason score lower than 6 caused greater diagnostic problems for referring physicians because these tumors had a greater number of malignant glands, yet were still sent in for consultation (P = .0018). Gleason score was positively correlated with prominent nucleoli and amphophilic cytoplasm and inversely correlated with the presence of crystaUoids. Prominent nucleoli, which often are quoted as being essential for the diagnosis of prostate cancer, were not seen in 24% of the specimens and seen only rarely in another 25%. The diagnosis of prostate cancer is based on a constellation of features. Even in this series with a limited number of malignant glands, 85% of specimens contained three or more of the above-listed diagnostic features in addition to architectural atypia. HUM PATHOL 26:223 --229. Copyright © 1995 by W.B. Saunders Company Key words:p rostate, prostatic adenocarcinoma, crystalloids, needle biopsy, Gleason grade, prostatic intraepithelial neoplasia.
PY - 1995/2
Y1 - 1995/2
N2 - Over a period of 25 weeks 434 needle biopsy specimens of the prostate were sent to the author for consultation because of diagnostic concerns. The final diagnoses were cancer (69%), benign (13%), atypical but not diagnostic (10%), high grade prostatic intraepithelial neoplasia (PIN) (5%), and miscellaneous (3%). The most common benign entities mimicking cancer were atrophy (29 specimens) and adenosis (19 specimens). The 300 cancer specimens were analyzed further. Architecturally, the presence of small glands between larger benign glands was the most common pattern seen in 80% of carcinomas; haphazard growth patterns, single cells, and cribriform glands were seen less frequently. The following diagnostic features were helpful: nuclear enlargement (77% of specimens); prominent nucleoli (76%); pink acellular intraluminal secretions (53%); amphophilic cytoplasm (39%); blue-tinged mucinous secretions (34%); crystalloids (25%); PIN (13%); mitotic figures (11%); and perineural invasion (3%). The mean and median numbers of malignant glands in this series were 31 and 20, respectively (range, two to 300). Tumors with a Gleason score lower than 6 caused greater diagnostic problems for referring physicians because these tumors had a greater number of malignant glands, yet were still sent in for consultation (P = .0018). Gleason score was positively correlated with prominent nucleoli and amphophilic cytoplasm and inversely correlated with the presence of crystalloids. Prominent nucleoli, which often are quoted as being essential for the diagnosis of prostate cancer, were not seen in 24% of the specimens and seen only rarely in another 25%. The diagnosis of prostate cancer is based on a constellation of features. Even in this series with a limited number of malignant glands, 85% of specimens contained three or more of the above-listed diagnostic features in addition to architectural atypia.
AB - Over a period of 25 weeks 434 needle biopsy specimens of the prostate were sent to the author for consultation because of diagnostic concerns. The final diagnoses were cancer (69%), benign (13%), atypical but not diagnostic (10%), high grade prostatic intraepithelial neoplasia (PIN) (5%), and miscellaneous (3%). The most common benign entities mimicking cancer were atrophy (29 specimens) and adenosis (19 specimens). The 300 cancer specimens were analyzed further. Architecturally, the presence of small glands between larger benign glands was the most common pattern seen in 80% of carcinomas; haphazard growth patterns, single cells, and cribriform glands were seen less frequently. The following diagnostic features were helpful: nuclear enlargement (77% of specimens); prominent nucleoli (76%); pink acellular intraluminal secretions (53%); amphophilic cytoplasm (39%); blue-tinged mucinous secretions (34%); crystalloids (25%); PIN (13%); mitotic figures (11%); and perineural invasion (3%). The mean and median numbers of malignant glands in this series were 31 and 20, respectively (range, two to 300). Tumors with a Gleason score lower than 6 caused greater diagnostic problems for referring physicians because these tumors had a greater number of malignant glands, yet were still sent in for consultation (P = .0018). Gleason score was positively correlated with prominent nucleoli and amphophilic cytoplasm and inversely correlated with the presence of crystalloids. Prominent nucleoli, which often are quoted as being essential for the diagnosis of prostate cancer, were not seen in 24% of the specimens and seen only rarely in another 25%. The diagnosis of prostate cancer is based on a constellation of features. Even in this series with a limited number of malignant glands, 85% of specimens contained three or more of the above-listed diagnostic features in addition to architectural atypia.
KW - Gleason grade
KW - crystalloids
KW - needle biopsy
KW - prostate
KW - prostatic adenocarcinoma
KW - prostatic intraepithelial neoplasia
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U2 - 10.1016/0046-8177(95)90041-1
DO - 10.1016/0046-8177(95)90041-1
M3 - Article
C2 - 7860053
AN - SCOPUS:0028850857
SN - 0046-8177
VL - 26
SP - 223
EP - 229
JO - Human pathology
JF - Human pathology
IS - 2
ER -