Diagnostic criteria for psychosis in Parkinson's disease: Report of an NINDS, NIMH Work Group

Bernard Ravina, Karen Marder, Hubert H. Fernandez, Joseph H. Friedman, William McDonald, Diane Murphy, Dag Aarsland, Debra Babcock, Jefferey Cummings, Jean Endicott, Stewart Factor, Wendy Galpern, Andrew Lees, Laura Marsh, Mark Stacy, Katrina Gwinn-Hardy, Valerie Voon, Christopher Goetz

Research output: Contribution to journalArticle

Abstract

There are no standardized diagnostic criteria for psychosis associated with Parkinson's disease (PDPsy). As part of an NIH sponsored workshop, we reviewed the existing literature on PDPsy to provide criteria that distinguish PDPsy from other causes of psychosis. Based on these data, we propose provisional criteria for PDPsy in the style of the Diagnostic and Statistical Manual of Mental Disorders IV-TR. PDPsy has a well-characterized temporal and clinical profile of hallucinations and delusions, which is different than the pattern seen in other psychotic disorders such as substance induced psychosis or schizophrenia. PDPsy is associated with a poor prognosis of chronic psychosis, nursing home placement, and death. Medications used to treat Parkinson's disease (PD) contribute to PDPsy but may not be sufficient or necessary contributors to PDPsy. PDPsy is associated with Lewy bodies pathology, imbalances of monoaminergic neurotransmitters, and visuospatial processing deficits. These findings suggest that PDPsy may result from progression of the disease process underlying PD, rather than a comorbid psychiatric disorder or drug intoxication. PDPsy is not adequately described by existing criteria for psychotic disorders. We established provisional diagnostic criteria that define a constellation of clinical features not shared by other psychotic syndromes. The criteria are inclusive and contain descriptions of the full range of characteristic symptoms, chronology of onset, duration of symptoms, exclusionary diagnoses, and associated features such as dementia. These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development.

Original languageEnglish (US)
Pages (from-to)1061-1068
Number of pages8
JournalMovement disorders : official journal of the Movement Disorder Society
Volume22
Issue number8
DOIs
StatePublished - Jun 15 2007

Fingerprint

National Institute of Neurological Disorders and Stroke
National Institute of Mental Health (U.S.)
Psychotic Disorders
Parkinson Disease
Substance-Induced Psychoses
Chronology
Lewy Bodies
Delusions
Hallucinations
Nursing Homes
Diagnostic and Statistical Manual of Mental Disorders
Neurotransmitter Agents
Psychiatry
Dementia
Disease Progression
Schizophrenia
Epidemiology
Pathology
Education
Pharmaceutical Preparations

Keywords

  • Diagnosis
  • Parkinson's
  • Psychosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Diagnostic criteria for psychosis in Parkinson's disease : Report of an NINDS, NIMH Work Group. / Ravina, Bernard; Marder, Karen; Fernandez, Hubert H.; Friedman, Joseph H.; McDonald, William; Murphy, Diane; Aarsland, Dag; Babcock, Debra; Cummings, Jefferey; Endicott, Jean; Factor, Stewart; Galpern, Wendy; Lees, Andrew; Marsh, Laura; Stacy, Mark; Gwinn-Hardy, Katrina; Voon, Valerie; Goetz, Christopher.

In: Movement disorders : official journal of the Movement Disorder Society, Vol. 22, No. 8, 15.06.2007, p. 1061-1068.

Research output: Contribution to journalArticle

Ravina, B, Marder, K, Fernandez, HH, Friedman, JH, McDonald, W, Murphy, D, Aarsland, D, Babcock, D, Cummings, J, Endicott, J, Factor, S, Galpern, W, Lees, A, Marsh, L, Stacy, M, Gwinn-Hardy, K, Voon, V & Goetz, C 2007, 'Diagnostic criteria for psychosis in Parkinson's disease: Report of an NINDS, NIMH Work Group', Movement disorders : official journal of the Movement Disorder Society, vol. 22, no. 8, pp. 1061-1068. https://doi.org/10.1002/mds.21382
Ravina, Bernard ; Marder, Karen ; Fernandez, Hubert H. ; Friedman, Joseph H. ; McDonald, William ; Murphy, Diane ; Aarsland, Dag ; Babcock, Debra ; Cummings, Jefferey ; Endicott, Jean ; Factor, Stewart ; Galpern, Wendy ; Lees, Andrew ; Marsh, Laura ; Stacy, Mark ; Gwinn-Hardy, Katrina ; Voon, Valerie ; Goetz, Christopher. / Diagnostic criteria for psychosis in Parkinson's disease : Report of an NINDS, NIMH Work Group. In: Movement disorders : official journal of the Movement Disorder Society. 2007 ; Vol. 22, No. 8. pp. 1061-1068.
@article{1cc4d0210e0c483090a5a9c311a85ce6,
title = "Diagnostic criteria for psychosis in Parkinson's disease: Report of an NINDS, NIMH Work Group",
abstract = "There are no standardized diagnostic criteria for psychosis associated with Parkinson's disease (PDPsy). As part of an NIH sponsored workshop, we reviewed the existing literature on PDPsy to provide criteria that distinguish PDPsy from other causes of psychosis. Based on these data, we propose provisional criteria for PDPsy in the style of the Diagnostic and Statistical Manual of Mental Disorders IV-TR. PDPsy has a well-characterized temporal and clinical profile of hallucinations and delusions, which is different than the pattern seen in other psychotic disorders such as substance induced psychosis or schizophrenia. PDPsy is associated with a poor prognosis of chronic psychosis, nursing home placement, and death. Medications used to treat Parkinson's disease (PD) contribute to PDPsy but may not be sufficient or necessary contributors to PDPsy. PDPsy is associated with Lewy bodies pathology, imbalances of monoaminergic neurotransmitters, and visuospatial processing deficits. These findings suggest that PDPsy may result from progression of the disease process underlying PD, rather than a comorbid psychiatric disorder or drug intoxication. PDPsy is not adequately described by existing criteria for psychotic disorders. We established provisional diagnostic criteria that define a constellation of clinical features not shared by other psychotic syndromes. The criteria are inclusive and contain descriptions of the full range of characteristic symptoms, chronology of onset, duration of symptoms, exclusionary diagnoses, and associated features such as dementia. These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development.",
keywords = "Diagnosis, Parkinson's, Psychosis",
author = "Bernard Ravina and Karen Marder and Fernandez, {Hubert H.} and Friedman, {Joseph H.} and William McDonald and Diane Murphy and Dag Aarsland and Debra Babcock and Jefferey Cummings and Jean Endicott and Stewart Factor and Wendy Galpern and Andrew Lees and Laura Marsh and Mark Stacy and Katrina Gwinn-Hardy and Valerie Voon and Christopher Goetz",
year = "2007",
month = "6",
day = "15",
doi = "10.1002/mds.21382",
language = "English (US)",
volume = "22",
pages = "1061--1068",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Diagnostic criteria for psychosis in Parkinson's disease

T2 - Report of an NINDS, NIMH Work Group

AU - Ravina, Bernard

AU - Marder, Karen

AU - Fernandez, Hubert H.

AU - Friedman, Joseph H.

AU - McDonald, William

AU - Murphy, Diane

AU - Aarsland, Dag

AU - Babcock, Debra

AU - Cummings, Jefferey

AU - Endicott, Jean

AU - Factor, Stewart

AU - Galpern, Wendy

AU - Lees, Andrew

AU - Marsh, Laura

AU - Stacy, Mark

AU - Gwinn-Hardy, Katrina

AU - Voon, Valerie

AU - Goetz, Christopher

PY - 2007/6/15

Y1 - 2007/6/15

N2 - There are no standardized diagnostic criteria for psychosis associated with Parkinson's disease (PDPsy). As part of an NIH sponsored workshop, we reviewed the existing literature on PDPsy to provide criteria that distinguish PDPsy from other causes of psychosis. Based on these data, we propose provisional criteria for PDPsy in the style of the Diagnostic and Statistical Manual of Mental Disorders IV-TR. PDPsy has a well-characterized temporal and clinical profile of hallucinations and delusions, which is different than the pattern seen in other psychotic disorders such as substance induced psychosis or schizophrenia. PDPsy is associated with a poor prognosis of chronic psychosis, nursing home placement, and death. Medications used to treat Parkinson's disease (PD) contribute to PDPsy but may not be sufficient or necessary contributors to PDPsy. PDPsy is associated with Lewy bodies pathology, imbalances of monoaminergic neurotransmitters, and visuospatial processing deficits. These findings suggest that PDPsy may result from progression of the disease process underlying PD, rather than a comorbid psychiatric disorder or drug intoxication. PDPsy is not adequately described by existing criteria for psychotic disorders. We established provisional diagnostic criteria that define a constellation of clinical features not shared by other psychotic syndromes. The criteria are inclusive and contain descriptions of the full range of characteristic symptoms, chronology of onset, duration of symptoms, exclusionary diagnoses, and associated features such as dementia. These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development.

AB - There are no standardized diagnostic criteria for psychosis associated with Parkinson's disease (PDPsy). As part of an NIH sponsored workshop, we reviewed the existing literature on PDPsy to provide criteria that distinguish PDPsy from other causes of psychosis. Based on these data, we propose provisional criteria for PDPsy in the style of the Diagnostic and Statistical Manual of Mental Disorders IV-TR. PDPsy has a well-characterized temporal and clinical profile of hallucinations and delusions, which is different than the pattern seen in other psychotic disorders such as substance induced psychosis or schizophrenia. PDPsy is associated with a poor prognosis of chronic psychosis, nursing home placement, and death. Medications used to treat Parkinson's disease (PD) contribute to PDPsy but may not be sufficient or necessary contributors to PDPsy. PDPsy is associated with Lewy bodies pathology, imbalances of monoaminergic neurotransmitters, and visuospatial processing deficits. These findings suggest that PDPsy may result from progression of the disease process underlying PD, rather than a comorbid psychiatric disorder or drug intoxication. PDPsy is not adequately described by existing criteria for psychotic disorders. We established provisional diagnostic criteria that define a constellation of clinical features not shared by other psychotic syndromes. The criteria are inclusive and contain descriptions of the full range of characteristic symptoms, chronology of onset, duration of symptoms, exclusionary diagnoses, and associated features such as dementia. These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development.

KW - Diagnosis

KW - Parkinson's

KW - Psychosis

UR - http://www.scopus.com/inward/record.url?scp=34447577668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447577668&partnerID=8YFLogxK

U2 - 10.1002/mds.21382

DO - 10.1002/mds.21382

M3 - Article

C2 - 17266092

AN - SCOPUS:34447577668

VL - 22

SP - 1061

EP - 1068

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 8

ER -