Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina

Alexander Goldberg, Oren Zinder, Alexander Zdorovyak, Eric Diamond, Sophie Lischinsky, Luis Gruberg, Walter Markiewicz, Rafael Beyar, Doron Aronson

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Systemic markers of inflammation increase after percutaneous coronary intervention (PCI). The rise in inflammatory markers after PCI is frequently attributed to the inflammatory stimulus associated with coronary artery injury during balloon inflation and coronary stent implantation. The aim of this study was the determine whether diagnostic coronary angiography performed in patients with stable angina triggers a systemic inflammatory response. Methods: We prospectively studied patients with chronic stable angina undergoing either coronary angiography (n = 13) or coronary angiography followed by PCI (n = 13). Peripheral blood samples were obtained before and 24 hours, 48 hours, and 4 weeks after the procedure and analyzed for C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Patients with periprocedural myocardial necrosis were excluded. Results: There was a significant increase in CRP levels at 24 and 48 hours in both the coronary angiography (P

Original languageEnglish (US)
Pages (from-to)819-823
Number of pages5
JournalAmerican Heart Journal
Volume146
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina'. Together they form a unique fingerprint.

Cite this