Diagnostic challenges in thyroid cytopathology

Research output: Contribution to journalReview articlepeer-review


Fine needle aspiration (FNA) is a long-standing modality used to obtain diagnostic material from patients with thyroid nodules. However, some common and uncommon situations exist in which diagnostic categorization of an FNA specimen is not straightforward. Diagnostically challenging thyroid lesions are typically either benign entities with cytomorphology that mimics malignancy, or malignant entities with unusual cytomorphology that causes difficulty in classification. Awareness of such diagnostic challenges can help broaden one's differential diagnosis when encountering such lesions on FNA. However, in many instances a definitive diagnosis may not be possible and providing an indeterminate diagnosis is most appropriate.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalDiagnostic Histopathology
Issue number5
StatePublished - May 1 2016


  • Fine needle aspiration
  • Papillary thyroid carcinoma
  • The Bethesda System for Reporting Thyroid Cytopathology
  • Thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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