Diagnostic biomarkers

Anne Macgregor-Das, Michael S Goggins

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic adenocarcinoma is the fourth leading cause of cancer death and the most deadly of all solid malignancies. Current methods for the early detection and diagnosis of pancreatic adenocarcinoma are largely ineffective and not feasible for uncovering small, often treatable precursor lesions in the general population. The discovery of biomarkers that aid in the early detection of pancreatic cancer would help to improve outcomes in patients and be of invaluable clinical benefit. This review discusses important considerations for the development of diagnostic biomarkers and profiles the promising molecular markers that have been evaluated in recent years.

Original languageEnglish (US)
Title of host publicationPancreatic Cancer
PublisherSpringer New York
Pages659-680
Number of pages22
ISBN (Electronic)9781493971930
ISBN (Print)9781493971916
DOIs
StatePublished - Apr 11 2018

Keywords

  • CA19-9
  • Circulating tumor DNA
  • Early detection
  • EUS (endoscopic ultrasound)
  • IPMN (intraductal papillary mucinous neoplasm)
  • KRAS
  • MCNs (mucinous cystic neoplasms)
  • Mutation
  • Pancreatic cancer
  • Pancreatic cyst
  • Pancreatic juice
  • PanIN (pancreatic intraepithelial neoplasia)

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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