Diagnostic and therapeutic strategies for eosinophilic esophagitis

Asifa K. Zaidi, Ahad Mussarat, Anil Mishra

Research output: Contribution to journalReview article

Abstract

Eosinophilic esophagitis (EoE) is a recently recognized allergic disorder, characterized by eosophageal dysfunction, accumulation of ≥15 eosinophils/high-powered field, eosinophil microabssess, basal cell hyperplasia, extracellular eosinophilic granules in the esophageal epithelial mucosal biopsy and a lack of response to a 8-week proton pump inhibitor treatment. Despite the increased incidences and considerable progress made in understanding EoE pathogenesis, there are limited diagnostic and therapeutic options available for EoE. Currently, the only criterion for diagnosing EoE is repetitive esophageal endoscopic biopsies and histopathological evaluation. Antigen elimination or corticosteroid therapies are effective therapies for EoE but are expensive and have limitations, if continued in the long term. Hence, there is a great necessity for novel noninvasive diagnostic biomarkers that can easily diagnose EoE and assess effectiveness of therapy. Herein, we have provided an update on key molecules involved in the disease initiation, and progression and proposed novel noninvasive diagnostic molecules and strategies for EoE therapy.

Original languageEnglish (US)
Pages (from-to)351-367
Number of pages17
JournalClinical Practice
Volume11
Issue number3
DOIs
StatePublished - May 2014

Keywords

  • basophils
  • eosinophil
  • esophagitis
  • interleukin
  • invariant natural killer T cells
  • mast cell

ASJC Scopus subject areas

  • Pharmacology (medical)

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