TY - GEN
T1 - Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging
AU - Jo, J. A.
AU - Fang, Q.
AU - Papaioannou, T.
AU - Qiao, J. H.
AU - Fishbein, M. C.
AU - Beseth, B.
AU - Dorafshar, A. H.
AU - Reil, T.
AU - Baker, D.
AU - Freischlag, J.
AU - Shung, K. K.
AU - Sun, L.
AU - Marcu, L.
PY - 2006
Y1 - 2006
N2 - In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.
AB - In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as Thin, Fibrotic, Calcified, Low-Inflamed, Inflamed and Necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting Inflamed and Necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.
KW - Atherosclerosis
KW - Laguerre expansion technique
KW - Time-resolved fluorescence spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=34047122297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34047122297&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2006.259350
DO - 10.1109/IEMBS.2006.259350
M3 - Conference contribution
C2 - 17946129
AN - SCOPUS:34047122297
SN - 1424400325
SN - 9781424400324
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 2663
EP - 2666
BT - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Y2 - 30 August 2006 through 3 September 2006
ER -