Abstract
To the Editor: Lung-transplant rejection as manifested by coughing, fever, deterioration of pulmonary function, and bronchiolitis obliterans has emerged as the principal cause of morbidity and mortality in long-term survivors with allografts. 1, 2 The only method currently available for the definitive diagnosis of lung rejection — open-lung biopsy — is not practical for surveillance. We investigated whether immunoperoxidase techniques that detect Leu-7-positive lymphocytes in bronchial epithelium could be applied to surveillance for lung rejection. Leu-7 was chosen because the presence of intraepithelial lymphocytes expressing the Leu-7 antigen is a specific marker of renal-allograft rejection.3 The bronchial epithelium was examined because it.
Original language | English (US) |
---|---|
Pages (from-to) | 1129 |
Number of pages | 1 |
Journal | New England Journal of Medicine |
Volume | 318 |
Issue number | 17 |
DOIs | |
State | Published - Apr 28 1988 |
ASJC Scopus subject areas
- General Medicine