To the Editor: Lung-transplant rejection as manifested by coughing, fever, deterioration of pulmonary function, and bronchiolitis obliterans has emerged as the principal cause of morbidity and mortality in long-term survivors with allografts. 1, 2 The only method currently available for the definitive diagnosis of lung rejection — open-lung biopsy — is not practical for surveillance. We investigated whether immunoperoxidase techniques that detect Leu-7-positive lymphocytes in bronchial epithelium could be applied to surveillance for lung rejection. Leu-7 was chosen because the presence of intraepithelial lymphocytes expressing the Leu-7 antigen is a specific marker of renal-allograft rejection.3 The bronchial epithelium was examined because it.
ASJC Scopus subject areas