Diagnosis of Rejection of Lung Allografts

Ralph H. Hruban, William E. Beschorner, Prabodh K. Gupta, William A. Baumgartner, Stephen C. Achuff, Thomas A. Traill, Bruce A. Reitz, Grover M. Hutchins

Research output: Contribution to journalLetterpeer-review


To the Editor: Lung-transplant rejection as manifested by coughing, fever, deterioration of pulmonary function, and bronchiolitis obliterans has emerged as the principal cause of morbidity and mortality in long-term survivors with allografts. 1, 2 The only method currently available for the definitive diagnosis of lung rejection — open-lung biopsy — is not practical for surveillance. We investigated whether immunoperoxidase techniques that detect Leu-7-positive lymphocytes in bronchial epithelium could be applied to surveillance for lung rejection. Leu-7 was chosen because the presence of intraepithelial lymphocytes expressing the Leu-7 antigen is a specific marker of renal-allograft rejection.3 The bronchial epithelium was examined because it.

Original languageEnglish (US)
Pages (from-to)1129
Number of pages1
JournalNew England Journal of Medicine
Issue number17
StatePublished - Apr 28 1988

ASJC Scopus subject areas

  • Medicine(all)

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