Diagnosis of recurrent bladder cancer by microsatellite analysis of the urine sediment (MAUS)

Gabriel Steiner, M. P. Schoenberg, L. Mao, David Sidransky, S. C. Müller

Research output: Contribution to journalArticle

Abstract

A reliable, noninvasive method for the monitoring of patients with transitional cell carcinoma (TCC) of the bladder is of great clinical benefit. Cystoscopy, the "gold standard" in the follow up of these patients is invasive, expensive and causes discomfort. Recently, a new tool in the diagnosis of de novo bladder cancer could be established based on microsatellite analysis of the urine DNA. To investigate the value of this approach in the follow up of patients, we analyzed serial urine samples of 21 patients who were treated for TCC by 20 polymorphic microsatellite markers in a blinded fashion. Recurrent lesions could be detected in 10 of 11 cases, neoplastic cell populations could be correctly predicted in 2 patients 4 and 6 months before endoscopic evidence of a tumor. The test was negative in all patients with no recurrent lesions. Microsatellite analysis is a novel and potentially powerful method in the detection of recurrent bladder tumors.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalAktuelle Urologie
Volume31
Issue numberSUPPL. 1
Publication statusPublished - Sep 2000

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ASJC Scopus subject areas

  • Nephrology

Cite this

Steiner, G., Schoenberg, M. P., Mao, L., Sidransky, D., & Müller, S. C. (2000). Diagnosis of recurrent bladder cancer by microsatellite analysis of the urine sediment (MAUS). Aktuelle Urologie, 31(SUPPL. 1), 78-82.