TY - JOUR
T1 - Diagnosis of Hymenoptera hypersensitivity by skin testing with Hymenoptera venoms
AU - Zeleznick, L. D.
AU - Hunt, Kevin J.
AU - Sobotka, Anne K.
AU - Valentine, Martin D.
AU - Tippett, L. O.
AU - Lichtenstein, Lawrence M.
PY - 1977/1
Y1 - 1977/1
N2 - This double-blind study provides evidence that skin testing with dialyzed Hymenoptera venoms is a more accurate, reliable method of diagnosing hypersensitivity to the sting of honeybee, yellow jacket, yellow hornet, white-faced hornet, and wasp than is skin testing with the corresponding whole body diagnostic allergenic extract. Furthermore, the incidence of false-positives was greatly reduced by using the dialyzed Hymenoptera venom (HDV)* * Center Laboratories, 35 Channel Dr., Port Washington, N. Y. diagonostic. In this clinical trial, most sensitive individuals had skin test reactions greater than the diluent control at concentrations of 1 μg/ml or below. Levels of venom diagnostic of 100 μg/ml appeared to produce nonspecific local irritation. Skin test with whole body diagnostic allergenic extract did not produce a consistent differentiation between sensitive and nonsensitive individuals. No untoward reactions were seen using the dialyzed Hymenoptera venom (HDV) diagnostic.
AB - This double-blind study provides evidence that skin testing with dialyzed Hymenoptera venoms is a more accurate, reliable method of diagnosing hypersensitivity to the sting of honeybee, yellow jacket, yellow hornet, white-faced hornet, and wasp than is skin testing with the corresponding whole body diagnostic allergenic extract. Furthermore, the incidence of false-positives was greatly reduced by using the dialyzed Hymenoptera venom (HDV)* * Center Laboratories, 35 Channel Dr., Port Washington, N. Y. diagonostic. In this clinical trial, most sensitive individuals had skin test reactions greater than the diluent control at concentrations of 1 μg/ml or below. Levels of venom diagnostic of 100 μg/ml appeared to produce nonspecific local irritation. Skin test with whole body diagnostic allergenic extract did not produce a consistent differentiation between sensitive and nonsensitive individuals. No untoward reactions were seen using the dialyzed Hymenoptera venom (HDV) diagnostic.
UR - http://www.scopus.com/inward/record.url?scp=0017328742&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017328742&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(77)90169-5
DO - 10.1016/0091-6749(77)90169-5
M3 - Article
C2 - 64482
AN - SCOPUS:0017328742
SN - 0091-6749
VL - 59
SP - 2
EP - 9
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 1
ER -