Abstract
The antiphospholipid antibody syndrome consists of a presentation with venous thrombosis, arterial thrombosis (or vasculopathy), recurrent pregnancy loss, or thrombocytopenia, in the setting of high-titer anticardiolipin antibody or lupus anticoagulant. Characteristics of the lupus anticoagulant (an antibody detected by a functional assay) and anticardiolipin antibody are reviewed, in light of new information on the role of plasma proteins, especially B2- glycoprotein I. The advantages and disadvantages of screening and confirmatory assays for lupus anticoagulant are detailed, as well as modifications of the anticardiolipin antibody assay to improve sensitivity and specificity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 443-469 |
| Number of pages | 27 |
| Journal | Rheumatic Disease Clinics of North America |
| Volume | 20 |
| Issue number | 2 |
| State | Published - 1994 |
ASJC Scopus subject areas
- Rheumatology