Diagnosis of antiphospholipid antibodies

Research output: Contribution to journalReview articlepeer-review

Abstract

The antiphospholipid antibody syndrome consists of a presentation with venous thrombosis, arterial thrombosis (or vasculopathy), recurrent pregnancy loss, or thrombocytopenia, in the setting of high-titer anticardiolipin antibody or lupus anticoagulant. Characteristics of the lupus anticoagulant (an antibody detected by a functional assay) and anticardiolipin antibody are reviewed, in light of new information on the role of plasma proteins, especially B2- glycoprotein I. The advantages and disadvantages of screening and confirmatory assays for lupus anticoagulant are detailed, as well as modifications of the anticardiolipin antibody assay to improve sensitivity and specificity.

Original languageEnglish (US)
Pages (from-to)443-469
Number of pages27
JournalRheumatic Disease Clinics of North America
Volume20
Issue number2
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Rheumatology

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