Diagnosis of airway obstruction in the elderly: contribution of the SARA study.

Claudio Sorino, Salvatore Battaglia, Nicola Scichilone, Claudio Pedone, Raffaele Antonelli-Incalzi, Duane Sherrill, Vincenzo Bellia

Research output: Contribution to journalArticle

Abstract

The choice between lower limit of normal or fixed value of forced expiratory volume in one second/forced vital capacity ratio (FEV(1)/FVC) <0.70 as the criterion for confirming airway obstruction is an open issue. In this study, we compared the criteria of lower limit of normal and fixed FEV(1)/FVC for diagnosis of airway obstruction, with a focus on healthy elderly people. We selected 367 healthy nonsmoking subjects aged 65-93 years from 1971 participants in the population-based SARA (Salute Respiratoria nell'Anziano, Italian for "Respiratory Health in the Elderly") study, analyzed their spirometric data, and tested the relationship between spirometric indices and anthropometric variables. The lower limit of normal for FEV(1)/FVC was calculated as the fifth percentile of the normal distribution for selected subjects. While FEV(1) and FVC decreased significantly with aging, the relationship between FEV(1)/FVC and age was not statistically significant in men or women. The lower limit of normal for FEV(1)/FVC was 0.65 in men and 0.67 in women. Fifty-five participants (15%) had FEV(1)/FVC <0.70 and would have been inappropriately classified as obstructed according to the Global Initiative for Obstructive Lung Disease, American Thoracic Society/European Respiratory Society, and Canadian guidelines on chronic obstructive pulmonary disease. By applying different FEV(1)/FVC thresholds for the different age groups, as previously proposed in the literature, (0.70 for 80 years) the percentage of patients classified as obstructed decreased to 6%. No subjects older than 80 years had an FEV(1)/FVC <0.60. The present results confirm the inadequacy of FEV(1)/FVC <0.70 as a diagnostic criterion for airway obstruction after the age of 65 years. FEV(1)/FVC <0.65 and

Original languageEnglish (US)
Pages (from-to)389-395
Number of pages7
JournalInternational Journal of COPD
Volume7
StatePublished - 2012
Externally publishedYes

Fingerprint

Airway Obstruction
Obstructive Lung Diseases
Normal Distribution
Vital Capacity
Forced Expiratory Volume
Chronic Obstructive Pulmonary Disease
Healthy Volunteers
Age Groups
Guidelines
Health
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sorino, C., Battaglia, S., Scichilone, N., Pedone, C., Antonelli-Incalzi, R., Sherrill, D., & Bellia, V. (2012). Diagnosis of airway obstruction in the elderly: contribution of the SARA study. International Journal of COPD, 7, 389-395.

Diagnosis of airway obstruction in the elderly : contribution of the SARA study. / Sorino, Claudio; Battaglia, Salvatore; Scichilone, Nicola; Pedone, Claudio; Antonelli-Incalzi, Raffaele; Sherrill, Duane; Bellia, Vincenzo.

In: International Journal of COPD, Vol. 7, 2012, p. 389-395.

Research output: Contribution to journalArticle

Sorino, C, Battaglia, S, Scichilone, N, Pedone, C, Antonelli-Incalzi, R, Sherrill, D & Bellia, V 2012, 'Diagnosis of airway obstruction in the elderly: contribution of the SARA study.', International Journal of COPD, vol. 7, pp. 389-395.
Sorino C, Battaglia S, Scichilone N, Pedone C, Antonelli-Incalzi R, Sherrill D et al. Diagnosis of airway obstruction in the elderly: contribution of the SARA study. International Journal of COPD. 2012;7:389-395.
Sorino, Claudio ; Battaglia, Salvatore ; Scichilone, Nicola ; Pedone, Claudio ; Antonelli-Incalzi, Raffaele ; Sherrill, Duane ; Bellia, Vincenzo. / Diagnosis of airway obstruction in the elderly : contribution of the SARA study. In: International Journal of COPD. 2012 ; Vol. 7. pp. 389-395.
@article{0780f63da42d4a5f8f3677d116b28396,
title = "Diagnosis of airway obstruction in the elderly: contribution of the SARA study.",
abstract = "The choice between lower limit of normal or fixed value of forced expiratory volume in one second/forced vital capacity ratio (FEV(1)/FVC) <0.70 as the criterion for confirming airway obstruction is an open issue. In this study, we compared the criteria of lower limit of normal and fixed FEV(1)/FVC for diagnosis of airway obstruction, with a focus on healthy elderly people. We selected 367 healthy nonsmoking subjects aged 65-93 years from 1971 participants in the population-based SARA (Salute Respiratoria nell'Anziano, Italian for {"}Respiratory Health in the Elderly{"}) study, analyzed their spirometric data, and tested the relationship between spirometric indices and anthropometric variables. The lower limit of normal for FEV(1)/FVC was calculated as the fifth percentile of the normal distribution for selected subjects. While FEV(1) and FVC decreased significantly with aging, the relationship between FEV(1)/FVC and age was not statistically significant in men or women. The lower limit of normal for FEV(1)/FVC was 0.65 in men and 0.67 in women. Fifty-five participants (15{\%}) had FEV(1)/FVC <0.70 and would have been inappropriately classified as obstructed according to the Global Initiative for Obstructive Lung Disease, American Thoracic Society/European Respiratory Society, and Canadian guidelines on chronic obstructive pulmonary disease. By applying different FEV(1)/FVC thresholds for the different age groups, as previously proposed in the literature, (0.70 for 80 years) the percentage of patients classified as obstructed decreased to 6{\%}. No subjects older than 80 years had an FEV(1)/FVC <0.60. The present results confirm the inadequacy of FEV(1)/FVC <0.70 as a diagnostic criterion for airway obstruction after the age of 65 years. FEV(1)/FVC <0.65 and",
author = "Claudio Sorino and Salvatore Battaglia and Nicola Scichilone and Claudio Pedone and Raffaele Antonelli-Incalzi and Duane Sherrill and Vincenzo Bellia",
year = "2012",
language = "English (US)",
volume = "7",
pages = "389--395",
journal = "International Journal of COPD",
issn = "1176-9106",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Diagnosis of airway obstruction in the elderly

T2 - contribution of the SARA study.

AU - Sorino, Claudio

AU - Battaglia, Salvatore

AU - Scichilone, Nicola

AU - Pedone, Claudio

AU - Antonelli-Incalzi, Raffaele

AU - Sherrill, Duane

AU - Bellia, Vincenzo

PY - 2012

Y1 - 2012

N2 - The choice between lower limit of normal or fixed value of forced expiratory volume in one second/forced vital capacity ratio (FEV(1)/FVC) <0.70 as the criterion for confirming airway obstruction is an open issue. In this study, we compared the criteria of lower limit of normal and fixed FEV(1)/FVC for diagnosis of airway obstruction, with a focus on healthy elderly people. We selected 367 healthy nonsmoking subjects aged 65-93 years from 1971 participants in the population-based SARA (Salute Respiratoria nell'Anziano, Italian for "Respiratory Health in the Elderly") study, analyzed their spirometric data, and tested the relationship between spirometric indices and anthropometric variables. The lower limit of normal for FEV(1)/FVC was calculated as the fifth percentile of the normal distribution for selected subjects. While FEV(1) and FVC decreased significantly with aging, the relationship between FEV(1)/FVC and age was not statistically significant in men or women. The lower limit of normal for FEV(1)/FVC was 0.65 in men and 0.67 in women. Fifty-five participants (15%) had FEV(1)/FVC <0.70 and would have been inappropriately classified as obstructed according to the Global Initiative for Obstructive Lung Disease, American Thoracic Society/European Respiratory Society, and Canadian guidelines on chronic obstructive pulmonary disease. By applying different FEV(1)/FVC thresholds for the different age groups, as previously proposed in the literature, (0.70 for 80 years) the percentage of patients classified as obstructed decreased to 6%. No subjects older than 80 years had an FEV(1)/FVC <0.60. The present results confirm the inadequacy of FEV(1)/FVC <0.70 as a diagnostic criterion for airway obstruction after the age of 65 years. FEV(1)/FVC <0.65 and

AB - The choice between lower limit of normal or fixed value of forced expiratory volume in one second/forced vital capacity ratio (FEV(1)/FVC) <0.70 as the criterion for confirming airway obstruction is an open issue. In this study, we compared the criteria of lower limit of normal and fixed FEV(1)/FVC for diagnosis of airway obstruction, with a focus on healthy elderly people. We selected 367 healthy nonsmoking subjects aged 65-93 years from 1971 participants in the population-based SARA (Salute Respiratoria nell'Anziano, Italian for "Respiratory Health in the Elderly") study, analyzed their spirometric data, and tested the relationship between spirometric indices and anthropometric variables. The lower limit of normal for FEV(1)/FVC was calculated as the fifth percentile of the normal distribution for selected subjects. While FEV(1) and FVC decreased significantly with aging, the relationship between FEV(1)/FVC and age was not statistically significant in men or women. The lower limit of normal for FEV(1)/FVC was 0.65 in men and 0.67 in women. Fifty-five participants (15%) had FEV(1)/FVC <0.70 and would have been inappropriately classified as obstructed according to the Global Initiative for Obstructive Lung Disease, American Thoracic Society/European Respiratory Society, and Canadian guidelines on chronic obstructive pulmonary disease. By applying different FEV(1)/FVC thresholds for the different age groups, as previously proposed in the literature, (0.70 for 80 years) the percentage of patients classified as obstructed decreased to 6%. No subjects older than 80 years had an FEV(1)/FVC <0.60. The present results confirm the inadequacy of FEV(1)/FVC <0.70 as a diagnostic criterion for airway obstruction after the age of 65 years. FEV(1)/FVC <0.65 and

UR - http://www.scopus.com/inward/record.url?scp=84871697795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871697795&partnerID=8YFLogxK

M3 - Article

C2 - 22848152

AN - SCOPUS:84871697795

VL - 7

SP - 389

EP - 395

JO - International Journal of COPD

JF - International Journal of COPD

SN - 1176-9106

ER -