Diagnosis and treatment of Huntington's disease

S. Folstein, Marshal F. Folstein

Research output: Contribution to journalArticle

Abstract

Huntington's disease (HD), formerly known as Huntington's chorea, was described in 1872 by George Huntington, an American physician. Huntington's disease is a disorder characterized by chorea and dementia usually beginning between the ages of 35 and 45 years and gradually worsening, ending in death an average of 15 years after onset. The most prominent neuropathologic finding is atrophy of the caudate nucleus and the putamen. Huntington's disease is the most frequent inherited neurologic disorder with a prevalence of 4 to 8 per 100,000. At least twice that many persons, the offspring of affected persons may develop HD at some time. This article reports the authors' experience of the systematic examination and treatment of 50 HD patients and more than 100 persons at risk.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalComprehensive Therapy
Volume7
Issue number4
StatePublished - 1981

Fingerprint

Huntington Disease
Therapeutics
Chorea
Caudate Nucleus
Putamen
Nervous System Diseases
Atrophy
Dementia
Physicians

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diagnosis and treatment of Huntington's disease. / Folstein, S.; Folstein, Marshal F.

In: Comprehensive Therapy, Vol. 7, No. 4, 1981, p. 60-66.

Research output: Contribution to journalArticle

@article{312ff64d01254673afe91ba08344ede9,
title = "Diagnosis and treatment of Huntington's disease",
abstract = "Huntington's disease (HD), formerly known as Huntington's chorea, was described in 1872 by George Huntington, an American physician. Huntington's disease is a disorder characterized by chorea and dementia usually beginning between the ages of 35 and 45 years and gradually worsening, ending in death an average of 15 years after onset. The most prominent neuropathologic finding is atrophy of the caudate nucleus and the putamen. Huntington's disease is the most frequent inherited neurologic disorder with a prevalence of 4 to 8 per 100,000. At least twice that many persons, the offspring of affected persons may develop HD at some time. This article reports the authors' experience of the systematic examination and treatment of 50 HD patients and more than 100 persons at risk.",
author = "S. Folstein and Folstein, {Marshal F.}",
year = "1981",
language = "English (US)",
volume = "7",
pages = "60--66",
journal = "Comprehensive Therapy",
issn = "0098-8243",
publisher = "Humana Press",
number = "4",

}

TY - JOUR

T1 - Diagnosis and treatment of Huntington's disease

AU - Folstein, S.

AU - Folstein, Marshal F.

PY - 1981

Y1 - 1981

N2 - Huntington's disease (HD), formerly known as Huntington's chorea, was described in 1872 by George Huntington, an American physician. Huntington's disease is a disorder characterized by chorea and dementia usually beginning between the ages of 35 and 45 years and gradually worsening, ending in death an average of 15 years after onset. The most prominent neuropathologic finding is atrophy of the caudate nucleus and the putamen. Huntington's disease is the most frequent inherited neurologic disorder with a prevalence of 4 to 8 per 100,000. At least twice that many persons, the offspring of affected persons may develop HD at some time. This article reports the authors' experience of the systematic examination and treatment of 50 HD patients and more than 100 persons at risk.

AB - Huntington's disease (HD), formerly known as Huntington's chorea, was described in 1872 by George Huntington, an American physician. Huntington's disease is a disorder characterized by chorea and dementia usually beginning between the ages of 35 and 45 years and gradually worsening, ending in death an average of 15 years after onset. The most prominent neuropathologic finding is atrophy of the caudate nucleus and the putamen. Huntington's disease is the most frequent inherited neurologic disorder with a prevalence of 4 to 8 per 100,000. At least twice that many persons, the offspring of affected persons may develop HD at some time. This article reports the authors' experience of the systematic examination and treatment of 50 HD patients and more than 100 persons at risk.

UR - http://www.scopus.com/inward/record.url?scp=0019797767&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019797767&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 60

EP - 66

JO - Comprehensive Therapy

JF - Comprehensive Therapy

SN - 0098-8243

IS - 4

ER -