Diagnosis and treatment of depression in Alzheimer's disease: Impact on mood and cognition

B. S. Appleby, P. Roy, A. Valenti, H. B. Lee

Research output: Contribution to journalReview articlepeer-review

Abstract

Depression, a common neuropsychiatric syndrome associated with lower quality of life (QOL), higher mortality, and higher caregiver burden, is estimated to occur in 20-50% of Alzheimer's disease (AD) patients. Recent research suggests that depression in AD (dAD) may differ from major depression phenomenologically and etiologically. Treatment options for dAD include behavioral modifications, pharmacotherapy, and electroconvulsive therapy. Successful treatment of dAD has been reported to improve patients' mood and QOL, as well as lower caregiver burden. Further research is needed in therapeutics of dAD to enhance treatment options and effectiveness.

Original languageEnglish (US)
Pages (from-to)139-149
Number of pages11
JournalPanminerva Medica
Volume49
Issue number3
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Alzheimer disease
  • Cognition
  • Depression, diagnosis

ASJC Scopus subject areas

  • Medicine(all)

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