Diagnosis and successful treatment of fusariosis in the compromised host

William G. Merz, Judith E. Karp, Melissa Hoagland, Mary Jett-Goheen, Jacqueline M. Junkins, Antoinette F. Hood

Research output: Contribution to journalArticlepeer-review

Abstract

We present six cases of fusariosis caused by Fusarium solani that were diagnosed over a three-year period in 166 adult patients undergoing chemotherapy for acute leukemia. Necrotic skin lesions were evident in four patients, fungemia in three, and a deep cellulitis around a great toe nail at the time of a febrile illness in two. The mean minimal inhibitory concentration (MIC) of amphotericin B was 3.3 μg/mL and of miconazole, 5.3 μg/mL; all isolates were resistant to 5-fluorocytosine. All patients received amphotericin B (1.0-1.5 mg/kg per d) plus 5-fluorocytosine. In contrast to results found in the literature, five patients had resolution of their infections, and the one patient who died had necropsy evidence of disseminated fusariosis. Review of our cases and of the literature did not reveal a definitive source for the organism or its portal of entry. Fusarium spp. must be recognized as opportunistic pathogens that cause a potentially fatal infection in compromised patients.

Original languageEnglish (US)
Pages (from-to)1046-1055
Number of pages10
JournalJournal of Infectious Diseases
Volume158
Issue number5
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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