Diagnosis and reversal of rejection in experimental and clinical lung allografts

F. J. Veith, S. K. Koerner, S. S. Siegelman, M. Kawakami, S. Kaufman, L. A. Attai, J. W. Hagstrom, M. L. Gliedman

Research output: Contribution to journalArticle

Abstract

Experience in patients and dogs with lung transplants has provided reliable criteria for diagnosing rejection and distinguishing it from other pathologic processes such as pneumonia and ischemic injury. These criteria include fever; dyspnea; malaise; increased sputum production; decreased arterial oxygen tension; and, most importantly, the rapid development (often within hours) of a roentgenographic alveolar infiltrate without any change in the sputum bacteriology. Using these criteria multiple rejection episodes in 2 patients and in comparably immunosuppressed dogs were identified. In almost every instance all acute manifestations of rejection, including the roentgenographic infiltrates, were completely reversed by three to seven large intravenous doses of methylprednisolone given at 12 to 24 hr intervals. In the dogs, reversal of rejection was also confirmed by gross and microscopical examination of the allograft. These findings show that acute rejection in lung allografts can be reliably identified by noninvasive criteria and successfully reversed.

Original languageEnglish (US)
Pages (from-to)172-183
Number of pages12
JournalAnnals of Thoracic Surgery
Volume16
Issue number2
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Allografts
Dogs
Sputum
Lung
Bacteriology
Methylprednisolone
Pathologic Processes
Dyspnea
Pneumonia
Arterial Pressure
Fever
Oxygen
Transplants
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Veith, F. J., Koerner, S. K., Siegelman, S. S., Kawakami, M., Kaufman, S., Attai, L. A., ... Gliedman, M. L. (1973). Diagnosis and reversal of rejection in experimental and clinical lung allografts. Annals of Thoracic Surgery, 16(2), 172-183. https://doi.org/10.1016/S0003-4975(10)65834-1

Diagnosis and reversal of rejection in experimental and clinical lung allografts. / Veith, F. J.; Koerner, S. K.; Siegelman, S. S.; Kawakami, M.; Kaufman, S.; Attai, L. A.; Hagstrom, J. W.; Gliedman, M. L.

In: Annals of Thoracic Surgery, Vol. 16, No. 2, 1973, p. 172-183.

Research output: Contribution to journalArticle

Veith, FJ, Koerner, SK, Siegelman, SS, Kawakami, M, Kaufman, S, Attai, LA, Hagstrom, JW & Gliedman, ML 1973, 'Diagnosis and reversal of rejection in experimental and clinical lung allografts', Annals of Thoracic Surgery, vol. 16, no. 2, pp. 172-183. https://doi.org/10.1016/S0003-4975(10)65834-1
Veith, F. J. ; Koerner, S. K. ; Siegelman, S. S. ; Kawakami, M. ; Kaufman, S. ; Attai, L. A. ; Hagstrom, J. W. ; Gliedman, M. L. / Diagnosis and reversal of rejection in experimental and clinical lung allografts. In: Annals of Thoracic Surgery. 1973 ; Vol. 16, No. 2. pp. 172-183.
@article{d256de7e06e64c4aa74673cbedaea4f1,
title = "Diagnosis and reversal of rejection in experimental and clinical lung allografts",
abstract = "Experience in patients and dogs with lung transplants has provided reliable criteria for diagnosing rejection and distinguishing it from other pathologic processes such as pneumonia and ischemic injury. These criteria include fever; dyspnea; malaise; increased sputum production; decreased arterial oxygen tension; and, most importantly, the rapid development (often within hours) of a roentgenographic alveolar infiltrate without any change in the sputum bacteriology. Using these criteria multiple rejection episodes in 2 patients and in comparably immunosuppressed dogs were identified. In almost every instance all acute manifestations of rejection, including the roentgenographic infiltrates, were completely reversed by three to seven large intravenous doses of methylprednisolone given at 12 to 24 hr intervals. In the dogs, reversal of rejection was also confirmed by gross and microscopical examination of the allograft. These findings show that acute rejection in lung allografts can be reliably identified by noninvasive criteria and successfully reversed.",
author = "Veith, {F. J.} and Koerner, {S. K.} and Siegelman, {S. S.} and M. Kawakami and S. Kaufman and Attai, {L. A.} and Hagstrom, {J. W.} and Gliedman, {M. L.}",
year = "1973",
doi = "10.1016/S0003-4975(10)65834-1",
language = "English (US)",
volume = "16",
pages = "172--183",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Diagnosis and reversal of rejection in experimental and clinical lung allografts

AU - Veith, F. J.

AU - Koerner, S. K.

AU - Siegelman, S. S.

AU - Kawakami, M.

AU - Kaufman, S.

AU - Attai, L. A.

AU - Hagstrom, J. W.

AU - Gliedman, M. L.

PY - 1973

Y1 - 1973

N2 - Experience in patients and dogs with lung transplants has provided reliable criteria for diagnosing rejection and distinguishing it from other pathologic processes such as pneumonia and ischemic injury. These criteria include fever; dyspnea; malaise; increased sputum production; decreased arterial oxygen tension; and, most importantly, the rapid development (often within hours) of a roentgenographic alveolar infiltrate without any change in the sputum bacteriology. Using these criteria multiple rejection episodes in 2 patients and in comparably immunosuppressed dogs were identified. In almost every instance all acute manifestations of rejection, including the roentgenographic infiltrates, were completely reversed by three to seven large intravenous doses of methylprednisolone given at 12 to 24 hr intervals. In the dogs, reversal of rejection was also confirmed by gross and microscopical examination of the allograft. These findings show that acute rejection in lung allografts can be reliably identified by noninvasive criteria and successfully reversed.

AB - Experience in patients and dogs with lung transplants has provided reliable criteria for diagnosing rejection and distinguishing it from other pathologic processes such as pneumonia and ischemic injury. These criteria include fever; dyspnea; malaise; increased sputum production; decreased arterial oxygen tension; and, most importantly, the rapid development (often within hours) of a roentgenographic alveolar infiltrate without any change in the sputum bacteriology. Using these criteria multiple rejection episodes in 2 patients and in comparably immunosuppressed dogs were identified. In almost every instance all acute manifestations of rejection, including the roentgenographic infiltrates, were completely reversed by three to seven large intravenous doses of methylprednisolone given at 12 to 24 hr intervals. In the dogs, reversal of rejection was also confirmed by gross and microscopical examination of the allograft. These findings show that acute rejection in lung allografts can be reliably identified by noninvasive criteria and successfully reversed.

UR - http://www.scopus.com/inward/record.url?scp=0015708343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015708343&partnerID=8YFLogxK

U2 - 10.1016/S0003-4975(10)65834-1

DO - 10.1016/S0003-4975(10)65834-1

M3 - Article

VL - 16

SP - 172

EP - 183

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 2

ER -