TY - JOUR
T1 - Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era
AU - Montgomery, Elizabeth A.
AU - Voltaggio, Lysandra
PY - 2017
Y1 - 2017
N2 - Whereas in the past, pathologists were hesitant to diagnose high-grade dysplasia in patients with Barrett esophagus, because this diagnosis prompted esophagectomy, current international consensus is that endoscopic treatment is the management for high-grade dysplasia and intramucosal carcinoma. Furthermore, many centers advocate endoscopic ablation for low-grade dysplasia. As such, establishing a diagnosis of dysplasia has become the key step; separation between the grades of dysplasia is less critical. This article offers some criteria for separating dysplasia from reactive changes, discusses pitfalls in interpreting endoscopic mucosal resection specimens, and outlines management strategies.
AB - Whereas in the past, pathologists were hesitant to diagnose high-grade dysplasia in patients with Barrett esophagus, because this diagnosis prompted esophagectomy, current international consensus is that endoscopic treatment is the management for high-grade dysplasia and intramucosal carcinoma. Furthermore, many centers advocate endoscopic ablation for low-grade dysplasia. As such, establishing a diagnosis of dysplasia has become the key step; separation between the grades of dysplasia is less critical. This article offers some criteria for separating dysplasia from reactive changes, discusses pitfalls in interpreting endoscopic mucosal resection specimens, and outlines management strategies.
KW - Barrett dysplasia
KW - Barrett neoplasia
KW - Endoscopic mucosal resection
KW - Endoscopic submucosal dissection
KW - Radiofrequency ablation
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U2 - 10.1016/j.path.2017.07.002
DO - 10.1016/j.path.2017.07.002
M3 - Article
C2 - 29103533
AN - SCOPUS:85029754693
SN - 1875-9181
JO - Surgical Pathology Clinics
JF - Surgical Pathology Clinics
ER -