Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era

Research output: Contribution to journalArticle

Abstract

Whereas in the past, pathologists were hesitant to diagnose high-grade dysplasia in patients with Barrett esophagus, because this diagnosis prompted esophagectomy, current international consensus is that endoscopic treatment is the management for high-grade dysplasia and intramucosal carcinoma. Furthermore, many centers advocate endoscopic ablation for low-grade dysplasia. As such, establishing a diagnosis of dysplasia has become the key step; separation between the grades of dysplasia is less critical. This article offers some criteria for separating dysplasia from reactive changes, discusses pitfalls in interpreting endoscopic mucosal resection specimens, and outlines management strategies.

Original languageEnglish (US)
JournalSurgical Pathology Clinics
DOIs
StateAccepted/In press - 2017

Fingerprint

Neoplasms
Esophagectomy
Barrett Esophagus
Carcinoma
Therapeutics
Pathologists
Endoscopic Mucosal Resection

Keywords

  • Barrett dysplasia
  • Barrett neoplasia
  • Endoscopic mucosal resection
  • Endoscopic submucosal dissection
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine

Cite this

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title = "Diagnosis and Management of Barrett-Related Neoplasia in the Modern Era",
abstract = "Whereas in the past, pathologists were hesitant to diagnose high-grade dysplasia in patients with Barrett esophagus, because this diagnosis prompted esophagectomy, current international consensus is that endoscopic treatment is the management for high-grade dysplasia and intramucosal carcinoma. Furthermore, many centers advocate endoscopic ablation for low-grade dysplasia. As such, establishing a diagnosis of dysplasia has become the key step; separation between the grades of dysplasia is less critical. This article offers some criteria for separating dysplasia from reactive changes, discusses pitfalls in interpreting endoscopic mucosal resection specimens, and outlines management strategies.",
keywords = "Barrett dysplasia, Barrett neoplasia, Endoscopic mucosal resection, Endoscopic submucosal dissection, Radiofrequency ablation",
author = "Lysandra Voltaggio and Montgomery, {Elizabeth A}",
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journal = "Surgical Pathology Clinics",
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AB - Whereas in the past, pathologists were hesitant to diagnose high-grade dysplasia in patients with Barrett esophagus, because this diagnosis prompted esophagectomy, current international consensus is that endoscopic treatment is the management for high-grade dysplasia and intramucosal carcinoma. Furthermore, many centers advocate endoscopic ablation for low-grade dysplasia. As such, establishing a diagnosis of dysplasia has become the key step; separation between the grades of dysplasia is less critical. This article offers some criteria for separating dysplasia from reactive changes, discusses pitfalls in interpreting endoscopic mucosal resection specimens, and outlines management strategies.

KW - Barrett dysplasia

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KW - Endoscopic mucosal resection

KW - Endoscopic submucosal dissection

KW - Radiofrequency ablation

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