Diagnosis and management of acute myelopathies

Adam I Kaplin, Chitra Krishnan, Deepa M. Deshpande, Carlos A Pardo-Villamizar, Douglas A. Kerr

Research output: Contribution to journalArticle

Abstract

Background: Acute myelopathies represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. Transverse myelitis (TM) is a prototype member of this group in which an immune-mediated process causes neural injury to the spinal cord, resulting in varying degrees of weakness, sensory alterations, and autonomic dysfunction. TM may exist as part of a multifocal CNS disease (eg, MS), multisystemic disease (eg, systemic lupus erythematosus), or as an isolated, idiopathic entity. Review Summary: In this article, we summarize recent classification and diagnostic schemes, which provide a framework for the diagnosis and management of patients with acute myelopathy. Additionally, we review the state of current knowledge about the epidemiology, natural history, immunopathogenesis, and treatment strategies for patients with TM. Conclusions: Our understanding of the classification, diagnosis, pathogenesis, and treatment of TM has recently begun to expand dramatically. With more rigorous criteria applied to distinguish acute myelopathies and with an emerging understanding of immunopathogenic events that underlie TM, it may now be possible to effectively initiate treatments in many of these disorders. Through the investigation of TM, we are also gaining a broader appreciation of the mechanisms that lead to autoimmune neurologic diseases in general.

Original languageEnglish (US)
Pages (from-to)2-18
Number of pages17
JournalNeurologist
Volume11
Issue number1
DOIs
StatePublished - Jan 2005

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Transverse Myelitis
Spinal Cord Diseases
Autoimmune Diseases of the Nervous System
Central Nervous System Diseases
Natural History
Spinal Cord Injuries
Systemic Lupus Erythematosus
Epidemiology
Therapeutics

Keywords

  • Myelopathy
  • Neuroinflammatory
  • Transverse myelitis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Diagnosis and management of acute myelopathies. / Kaplin, Adam I; Krishnan, Chitra; Deshpande, Deepa M.; Pardo-Villamizar, Carlos A; Kerr, Douglas A.

In: Neurologist, Vol. 11, No. 1, 01.2005, p. 2-18.

Research output: Contribution to journalArticle

Kaplin, Adam I ; Krishnan, Chitra ; Deshpande, Deepa M. ; Pardo-Villamizar, Carlos A ; Kerr, Douglas A. / Diagnosis and management of acute myelopathies. In: Neurologist. 2005 ; Vol. 11, No. 1. pp. 2-18.
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