Diagnosing the correct ovarian cancer syndrome

Edward Trimble, Beth Y. Karlan, Leo D. Lagasse, William J. Hoskins

Research output: Contribution to journalArticle


We report four sisters whose maternal pedigree suggested a site-specific ovarian cancer syndrome, whereas their paternal pedigree closely fit the Cancer Family Syndrome (Lynch II). Eliciting a complete family history, both maternal and paternal, is important for defining the correct ovarian cancer syndrome. Once the definition is made, the patient and other family members at risk must be counseled and encouraged to begin the appropriate schedule of screening and intervention. These recommendations may be summarized as follows: 1) site-specific ovarian carcinoma: screening with physical examination, CA 125, and ultrasound, and bilateral oophorectomy after childbearing has been completed; 2) breast/ovary syndrome: screening for ovarian cancer as above, mammography and bilateral oophorectomy as above, and possible prophylactic mastectomy; and 3) Lynch Cancer Family Syndrome: screening for ovarian cancer as above, colonoscopy and endometrial biopsy, and prophylactic hysterectomy and bilateral oophorectomy once childbearing is complete.

Original languageEnglish (US)
Pages (from-to)1023-1026
Number of pages4
JournalObstetrics and Gynecology
Issue number6
Publication statusPublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Trimble, E., Karlan, B. Y., Lagasse, L. D., & Hoskins, W. J. (1991). Diagnosing the correct ovarian cancer syndrome. Obstetrics and Gynecology, 78(6), 1023-1026.