Diagnosing and treating the failing right heart

John J. Ryan, Ryan J. Tedford

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of review Right ventricular failure (RVF) is associated with significant morbidity and mortality. There is an increasing interest in proper assessment of right ventricle (RV) function as well as understanding mechanisms behind RVF. Recent findings Within this article, we discuss the metabolic changes that occur in the RV in response to RVF, in particular, a shift toward glycolysis and increased glutaminolysis. We will detail the advances made in noninvasive imaging in assessing the function of the RV and review the methods to assess right ventricle-pulmonary artery coupling. We lastly investigate the role of new treatment options in the failing RV, such as β-blocker therapy. Summary RVF is a complicated entity. Although some inferences on RV function and treatment can be made from our understanding of the left ventricle, the RV has unique features, anatomically, metabolically and embryologically, that require dedicated RV-directed research.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalCurrent opinion in cardiology
Volume30
Issue number3
DOIs
StatePublished - May 27 2015

Keywords

  • Randle's cycle
  • Warburg effect
  • glycolysis
  • right heart failure
  • right ventricle
  • ventricular-vascular coupling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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