Diabetic retinopathy

current understanding, mechanisms, and treatment strategies

Elia J Duh, Jennifer K. Sun, Alan W. Stitt

Research output: Contribution to journalReview article

Abstract

Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) have greatly improved over the past decade. However, additional therapeutic options are needed that take into account pathology associated with vascular, glial, and neuronal components of the diabetic retina. Recent work indicates that diabetes markedly impacts the retinal neurovascular unit and its interdependent vascular, neuronal, glial, and immune cells. This knowledge is leading to identification of new targets and therapeutic strategies for preventing or reversing retinal neuronal dysfunction, vascular leakage, ischemia, and pathologic angiogenesis. These advances, together with approaches embracing the potential of preventative or regenerative medicine, could provide the means to better manage DR, including treatment at earlier stages and more precise tailoring of treatments based on individual patient variations.

Original languageEnglish (US)
JournalJCI insight
Volume2
Issue number14
DOIs
StatePublished - Jul 20 2017

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Diabetic Retinopathy
Blood Vessels
Neuroglia
Pathologic Neovascularization
Therapeutics
Preventive Medicine
Regenerative Medicine
Macular Edema
Diabetes Complications
Retina
Ischemia
Pathology

Cite this

Diabetic retinopathy : current understanding, mechanisms, and treatment strategies. / Duh, Elia J; Sun, Jennifer K.; Stitt, Alan W.

In: JCI insight, Vol. 2, No. 14, 20.07.2017.

Research output: Contribution to journalReview article

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