TY - JOUR
T1 - Diabetic kidney disease
T2 - Pathophysiology and therapeutic targets
AU - Toth-Manikowski, Stephanie
AU - Atta, Mohamed G.
N1 - Publisher Copyright:
Copyright © 2015 S. Toth-Manikowski and M. G. Atta. This is an open access article distributed under the Creative Commons.
PY - 2015
Y1 - 2015
N2 - Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients with this disorder. Indeed, treatment is primarily centered on controlling hyperglycemia and hypertension and inhibiting the renin-angiotensin system. The purpose of this review is to describe the current understanding of how the hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled in pathogenesis of DKD and detail the various therapeutic targets that may one day play a role in quelling this epidemic.
AB - Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD). Over the past two decades, there has been significant clarification of the various pathways implicated in the pathogenesis of DKD. Nonetheless, very little has changed in the way clinicians manage patients with this disorder. Indeed, treatment is primarily centered on controlling hyperglycemia and hypertension and inhibiting the renin-angiotensin system. The purpose of this review is to describe the current understanding of how the hemodynamic, metabolic, inflammatory, and alternative pathways are all entangled in pathogenesis of DKD and detail the various therapeutic targets that may one day play a role in quelling this epidemic.
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U2 - 10.1155/2015/697010
DO - 10.1155/2015/697010
M3 - Review article
C2 - 26064987
AN - SCOPUS:84929325840
SN - 2314-6745
VL - 2015
JO - Journal of diabetes research
JF - Journal of diabetes research
M1 - 697010
ER -