Diabetes-related mortality in adults with cystic fibrosis: Role of genotype and sex

Connor Lewis, Scott M. Blackman, Amanda Nelson, Ewa Oberdorfer, Daniel Wells, Jordan Dunitz, William Thomas, Antoinette Moran

Research output: Contribution to journalArticlepeer-review

Abstract

Rationale: Diabetes is associated with increased mortality in cystic fibrosis. Aggressive screening and early institution of insulin treatment significantly reduced this risk over the period of 1992-2008. Objectives: To determine if progressive improvement in cystic fibrosis-related diabetes (CFRD) mortality has continued since 2008, and examine associations with CFTR genotypes linked to pancreatic insufficiency and to sex. Methods: Chart review was performed on 664 patients followed from 2008 to 2012. Measurements and Main Results: Overall mortality for patients with CFRD was 1.8 per 100 person-years, compared with 0.5 in patients with CF without diabetes ( P = 0.0002); neither rate changed significantly from mortality reported for 2003-2008. Genotype impacted both mortality and diabetes risk: adults with severe CFTR genotypes experienced greater mortality at every age older than 32 years than those with mild genotypes (P = 0.002), and the risk of developing CFRD was also greatly increased in those with severe genotypes (prevalence 60% in adult patients with severe vs. 14% in adults with mild mutations). CFRD had a direct influence on mortality because it was associated with increased risk of death within each genotype category (20 vs. 2%, P = 0.007 for mild; 12 vs. 4%, P = 0.012 for severe). There was also a sex difference in adults with severe CFTR genotypes; both mortality and CFRD prevalence were higher at every age in females than males. Conclusions: Despite substantial improvement over time, mortality for CFRD patients greater than 30 years remains higher than for patients with CF without diabetes.

Original languageEnglish (US)
Pages (from-to)194-200
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume191
Issue number2
DOIs
StatePublished - Jan 15 2015

Keywords

  • Cystic fibrosis-related diabetes
  • Prognosis
  • Sex differences
  • Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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