Diabetes as a complication of tacrolimus (FK506) in pediatric renal transplant patients

Susan Furth, Alicia Neu, Paul Colombani, Leslie Plotnick, Mary Ellen Turner, Barbara Fivush

Research output: Contribution to journalArticlepeer-review

Abstract

Three cases of insulin-requiring diabetes mellitus associated with tacrolimus (FK506) therapy in pediatric renal transplant patients are presented. New-onset diabetes mellitus has been reported with tacrolimus therapy post liver and kidney transplants in up to 12% of adult patients, but is thought to be rare in pediatrics. Although insulin requirement with tacrolimus therapy has been occasionally reported in adolescent patients post liver transplant, only a single case in a pediatric kidney transplant recipient has been previously documented. These cases illustrate the significant diabetogenic effect of tacrolimus in pediatric renal transplant patients. As the use of tacrolimus becomes more prevalent in pediatric kidney transplantation, pediatric nephrologists should be aware of this potential complication.

Original languageEnglish (US)
Pages (from-to)64-66
Number of pages3
JournalPediatric Nephrology
Volume10
Issue number1
DOIs
StatePublished - Feb 1 1996

Keywords

  • Diabetes mellitus
  • Kidney transplantation
  • Tacrolimus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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