Diabetes and O-Glcnacylation

Yoshihiro Akimoto, Yuri Miura, Tamao Endo, Hayato Kawakami, Gerald Warren Hart

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

O-Linked β-N-acetylglucosamine modification (O-GlcNAcylation) of proteins is a dynamic posttranslational modification which occurs in the nucleus and the cytoplasm. Increase of O-GlcNAcylation is involved in the glucose toxicity and chronic hyperglycemia-induced insulin resistance, a major hallmark of type 2 diabetes. O-GlcNAcylation is regulated by the concerted actions of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Studies on the overexpression of OGT and knockdown of OGA demonstrate that elevation of O-GlcNAcylation through the hexosamine biosynthetic pathway plays an important role in the development of glucose resistance and diabetic complications. This chapter overviews the role of O-GlcNAc in the type 2 diabetes and diabetic complications and the methods of analysis of O-GlcNAcylation in diabetes.

Original languageEnglish (US)
Title of host publicationGlycoscience: Biology and Medicine
PublisherSpringer Japan
Pages1207-1212
Number of pages6
ISBN (Print)9784431548416, 9784431548409
DOIs
StatePublished - Jan 1 2015

Keywords

  • Diabetes
  • Insulin resistance
  • O-GlcNAc transferase
  • O-GlcNAcase
  • O-GlcNAcylation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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