Diabetes and Clinical and Subclinical CVD

Alain G. Bertoni, Holly Kramer, Karol Watson, Wendy S Post

Research output: Contribution to journalReview article

Abstract

Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63% had CAC >0; above CAC >400 Agatston units the event rate was 4% annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4% to 0.1% annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology.

Original languageEnglish (US)
Pages (from-to)337-342
Number of pages6
JournalGlobal Heart
Volume11
Issue number3
DOIs
StatePublished - Sep 1 2016

Fingerprint

Coronary Vessels
Atherosclerosis
Cardiovascular Diseases
Carotid Intima-Media Thickness
Vascular Diseases
Carotid Arteries
Diabetes Mellitus
Epidemiology

ASJC Scopus subject areas

  • Epidemiology
  • Community and Home Care
  • Cardiology and Cardiovascular Medicine

Cite this

Diabetes and Clinical and Subclinical CVD. / Bertoni, Alain G.; Kramer, Holly; Watson, Karol; Post, Wendy S.

In: Global Heart, Vol. 11, No. 3, 01.09.2016, p. 337-342.

Research output: Contribution to journalReview article

Bertoni, AG, Kramer, H, Watson, K & Post, WS 2016, 'Diabetes and Clinical and Subclinical CVD', Global Heart, vol. 11, no. 3, pp. 337-342. https://doi.org/10.1016/j.gheart.2016.07.005
Bertoni, Alain G. ; Kramer, Holly ; Watson, Karol ; Post, Wendy S. / Diabetes and Clinical and Subclinical CVD. In: Global Heart. 2016 ; Vol. 11, No. 3. pp. 337-342.
@article{bc5b0de5b6e04472abb5b2a5bcda06c1,
title = "Diabetes and Clinical and Subclinical CVD",
abstract = "Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50{\%} female, 62{\%} nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63{\%} had CAC >0; above CAC >400 Agatston units the event rate was 4{\%} annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4{\%} to 0.1{\%} annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology.",
author = "Bertoni, {Alain G.} and Holly Kramer and Karol Watson and Post, {Wendy S}",
year = "2016",
month = "9",
day = "1",
doi = "10.1016/j.gheart.2016.07.005",
language = "English (US)",
volume = "11",
pages = "337--342",
journal = "Global Heart",
issn = "2211-8160",
publisher = "Elsevier Science & Technology",
number = "3",

}

TY - JOUR

T1 - Diabetes and Clinical and Subclinical CVD

AU - Bertoni, Alain G.

AU - Kramer, Holly

AU - Watson, Karol

AU - Post, Wendy S

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63% had CAC >0; above CAC >400 Agatston units the event rate was 4% annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4% to 0.1% annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology.

AB - Diabetes mellitus is a major cardiovascular risk factor and its prevalence has been increasing globally. This review examines the contributions of the MESA (Multi-Ethnic Study of Atherosclerosis), a diverse American cohort (6,814 adults ages 45 to 84, recruited from 2000 to 2002, 50% female, 62% nonwhite) toward understanding the relationship between diabetes and clinical and subclinical cardiovascular disease. People with diabetes have a high burden of subclinical vascular disease as measured by coronary artery calcification (CAC), carotid artery intima-media thickness, valvular calcification, and alterations in left ventricular structure. CAC substantially improves cardiovascular risk prediction. Among adults with diabetes, 63% had CAC >0; above CAC >400 Agatston units the event rate was 4% annually, whereas an absence of CAC was a marker of a very low cardiovascular disease rate (0.4% to 0.1% annually). These stark differences in rates may have implications for screening and/or targeted prevention efforts based on CAC burden. MESA has also provided insight on diabetes epidemiology.

UR - http://www.scopus.com/inward/record.url?scp=84992111305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992111305&partnerID=8YFLogxK

U2 - 10.1016/j.gheart.2016.07.005

DO - 10.1016/j.gheart.2016.07.005

M3 - Review article

C2 - 27741980

AN - SCOPUS:84992111305

VL - 11

SP - 337

EP - 342

JO - Global Heart

JF - Global Heart

SN - 2211-8160

IS - 3

ER -