Diabetes and Altered Glucose Metabolism with Aging

Rita Rastogi Kalyani; Josephine M. Egan

doi:10.1016/j.ecl.2013.02.010

Diabetes and Altered Glucose Metabolism with Aging

Rita Rastogi Kalyani, Josephine M. Egan

School of Medicine

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging. Older adults with diabetes and altered glucose status likely represent a subset of the population at high risk for complications and adverse geriatric syndromes. Goals for treatment of diabetes in the elderly include control of hyperglycemia, prevention and treatment of diabetic complications, avoidance of hypoglycemia, and preservation of quality of life. Research exploring associations of dysglycemia and insulin resistance with the development of adverse outcomes in the elderly may ultimately inform use of future glucose-lowering therapies in this population.

Original language	English (US)
Pages (from-to)	333-347
Number of pages	15
Journal	Endocrinology and metabolism clinics of North America
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/j.ecl.2013.02.010
State	Published - Jun 2013

Keywords

Aging
Beta-cell dysfunction
Diabetes
Insulin resistance

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ecl.2013.02.010

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title = "Diabetes and Altered Glucose Metabolism with Aging",

abstract = "Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging. Older adults with diabetes and altered glucose status likely represent a subset of the population at high risk for complications and adverse geriatric syndromes. Goals for treatment of diabetes in the elderly include control of hyperglycemia, prevention and treatment of diabetic complications, avoidance of hypoglycemia, and preservation of quality of life. Research exploring associations of dysglycemia and insulin resistance with the development of adverse outcomes in the elderly may ultimately inform use of future glucose-lowering therapies in this population.",

keywords = "Aging, Beta-cell dysfunction, Diabetes, Insulin resistance",

author = "Kalyani, {Rita Rastogi} and Egan, {Josephine M.}",

note = "Funding Information: Funding Sources: This work is supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases (R.R. Kalyani; K23DK093583 ) and the Intramural Research Program/National Institutes of Health , and the National Institute on Aging (J.M. Egan). ",

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AB - Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging. Older adults with diabetes and altered glucose status likely represent a subset of the population at high risk for complications and adverse geriatric syndromes. Goals for treatment of diabetes in the elderly include control of hyperglycemia, prevention and treatment of diabetic complications, avoidance of hypoglycemia, and preservation of quality of life. Research exploring associations of dysglycemia and insulin resistance with the development of adverse outcomes in the elderly may ultimately inform use of future glucose-lowering therapies in this population.

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KW - Insulin resistance

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Diabetes and Altered Glucose Metabolism with Aging

Abstract

Keywords

ASJC Scopus subject areas

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