DGK-θ: Structure, enzymology, and physiological roles

Becky Tu-Sekine, Hana L. Goldschmidt, Daniel M. Raben

Research output: Contribution to journalShort survey

Abstract

Diacylglycerol kinases (DGKs) are a family of enzymes that catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PtdOH). The recognition of the importance of these enzymes has been increasing ever since it was determined that they played a role in the phosphatidylinositol (PtdIns) cycle and a number of excellent reviews have already been written [(see van Blitterswijk and Houssa, 2000; Kanoh et al., 2002; Mérida et al., 2008; Tu-Sekine and Raben, 2009, 2011; Shulga et al., 2011; Tu-Sekine et al., 2013) among others]. We now know there are ten mammalian DGKs that are organized into five classes. DGK-θ is the lone member of the Type V class of DGKs and remains as one of the least studied. This review focuses on our current understanding of the structure, enzymology, regulation, and physiological roles of this DGK and suggests some future areas of research to understand this DGK isoform.

Original languageEnglish (US)
Article number101
JournalFrontiers in Cell and Developmental Biology
Volume4
Issue numberSEP
DOIs
StatePublished - Sep 14 2016

Keywords

  • Diacylglycerol kinase
  • Interfacial enzymology
  • Phosphatidic acid
  • Regulation
  • Synaptic vesicle cycle

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'DGK-θ: Structure, enzymology, and physiological roles'. Together they form a unique fingerprint.

  • Cite this