DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1

Jamil Ahmad, Shaheen N. Khan, Shahid Khan, Khushnooda Ramzan, Saima Riazuddin, Zubair M. Ahmed, Edward R. Wilcox, Thomas B. Friedman, Sheikh Riazuddin

Research output: Contribution to journalArticle

Abstract

Nonsyndromic deafness locus (DFNB48) segregating as an autosomal recessive trait has been mapped to the long arm of chromosome 15 in bands q23-q25.1 in five large Pakistani families. The deafness phenotype in one of these five families (PKDF245) is linked to D15S1005 with a lod score of 8.6 at θ = 0, and there is a critical linkage interval of approximately 7 cM on the Marshfield human genetic map, bounded by microsatellite markers D15S216 (70.73 cM) and D15S1041 (77.69 cM). MYO9A, NR2E3, BBS4, and TMC3 are among the candidate genes in the DFNB48 region. The identification of another novel nonsyndromic recessive deafness locus demonstrates the high degree of locus heterogeneity for hearing impairment, particularly in the Pakistani population. Loci have been mapped either in endogamous population or in families with children of consanguineous marriages (Friedman and Griffith 2003). As a consequence of the unique socio-cultural practices in the population of Pakistan, aproximately 60% of marriages are consanquineous, of wich more than 80% are between first counsin (Hussain and Bittles 1998). These large consanguineous families are a powerful resource for genetic linkage studies of recessively inherited dis-order. In this communication, we report a novel deafness locus DFNB48 genetically mapped with the aid of five consanguineous families from remote areas of Sindh Province in Pakistan. This locus resides in an interval of approximately 7 cM on chromosome 15q23-q25.1.

Original languageEnglish (US)
Pages (from-to)407-412
Number of pages6
JournalHuman genetics
Volume116
Issue number5
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Fingerprint

Chromosomes
Pakistan
Deafness
Marriage
Population
Lod Score
Chromosomes, Human, Pair 15
Genetic Linkage
Medical Genetics
Hearing Loss
Microsatellite Repeats
Autosomal Recessive 48 Deafness
Nonsyndromic Deafness
Phenotype
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Ahmad, J., Khan, S. N., Khan, S., Ramzan, K., Riazuddin, S., Ahmed, Z. M., ... Riazuddin, S. (2005). DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1. Human genetics, 116(5), 407-412. https://doi.org/10.1007/s00439-004-1247-y

DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1. / Ahmad, Jamil; Khan, Shaheen N.; Khan, Shahid; Ramzan, Khushnooda; Riazuddin, Saima; Ahmed, Zubair M.; Wilcox, Edward R.; Friedman, Thomas B.; Riazuddin, Sheikh.

In: Human genetics, Vol. 116, No. 5, 01.04.2005, p. 407-412.

Research output: Contribution to journalArticle

Ahmad, J, Khan, SN, Khan, S, Ramzan, K, Riazuddin, S, Ahmed, ZM, Wilcox, ER, Friedman, TB & Riazuddin, S 2005, 'DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1', Human genetics, vol. 116, no. 5, pp. 407-412. https://doi.org/10.1007/s00439-004-1247-y
Ahmad, Jamil ; Khan, Shaheen N. ; Khan, Shahid ; Ramzan, Khushnooda ; Riazuddin, Saima ; Ahmed, Zubair M. ; Wilcox, Edward R. ; Friedman, Thomas B. ; Riazuddin, Sheikh. / DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1. In: Human genetics. 2005 ; Vol. 116, No. 5. pp. 407-412.
@article{c490369e89f643d0a241f871c628a5e3,
title = "DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1",
abstract = "Nonsyndromic deafness locus (DFNB48) segregating as an autosomal recessive trait has been mapped to the long arm of chromosome 15 in bands q23-q25.1 in five large Pakistani families. The deafness phenotype in one of these five families (PKDF245) is linked to D15S1005 with a lod score of 8.6 at θ = 0, and there is a critical linkage interval of approximately 7 cM on the Marshfield human genetic map, bounded by microsatellite markers D15S216 (70.73 cM) and D15S1041 (77.69 cM). MYO9A, NR2E3, BBS4, and TMC3 are among the candidate genes in the DFNB48 region. The identification of another novel nonsyndromic recessive deafness locus demonstrates the high degree of locus heterogeneity for hearing impairment, particularly in the Pakistani population. Loci have been mapped either in endogamous population or in families with children of consanguineous marriages (Friedman and Griffith 2003). As a consequence of the unique socio-cultural practices in the population of Pakistan, aproximately 60{\%} of marriages are consanquineous, of wich more than 80{\%} are between first counsin (Hussain and Bittles 1998). These large consanguineous families are a powerful resource for genetic linkage studies of recessively inherited dis-order. In this communication, we report a novel deafness locus DFNB48 genetically mapped with the aid of five consanguineous families from remote areas of Sindh Province in Pakistan. This locus resides in an interval of approximately 7 cM on chromosome 15q23-q25.1.",
author = "Jamil Ahmad and Khan, {Shaheen N.} and Shahid Khan and Khushnooda Ramzan and Saima Riazuddin and Ahmed, {Zubair M.} and Wilcox, {Edward R.} and Friedman, {Thomas B.} and Sheikh Riazuddin",
year = "2005",
month = "4",
day = "1",
doi = "10.1007/s00439-004-1247-y",
language = "English (US)",
volume = "116",
pages = "407--412",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - DFNB48, a new nonsyndromic recessive deafness locus, maps to chromosome 15q23-q25.1

AU - Ahmad, Jamil

AU - Khan, Shaheen N.

AU - Khan, Shahid

AU - Ramzan, Khushnooda

AU - Riazuddin, Saima

AU - Ahmed, Zubair M.

AU - Wilcox, Edward R.

AU - Friedman, Thomas B.

AU - Riazuddin, Sheikh

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Nonsyndromic deafness locus (DFNB48) segregating as an autosomal recessive trait has been mapped to the long arm of chromosome 15 in bands q23-q25.1 in five large Pakistani families. The deafness phenotype in one of these five families (PKDF245) is linked to D15S1005 with a lod score of 8.6 at θ = 0, and there is a critical linkage interval of approximately 7 cM on the Marshfield human genetic map, bounded by microsatellite markers D15S216 (70.73 cM) and D15S1041 (77.69 cM). MYO9A, NR2E3, BBS4, and TMC3 are among the candidate genes in the DFNB48 region. The identification of another novel nonsyndromic recessive deafness locus demonstrates the high degree of locus heterogeneity for hearing impairment, particularly in the Pakistani population. Loci have been mapped either in endogamous population or in families with children of consanguineous marriages (Friedman and Griffith 2003). As a consequence of the unique socio-cultural practices in the population of Pakistan, aproximately 60% of marriages are consanquineous, of wich more than 80% are between first counsin (Hussain and Bittles 1998). These large consanguineous families are a powerful resource for genetic linkage studies of recessively inherited dis-order. In this communication, we report a novel deafness locus DFNB48 genetically mapped with the aid of five consanguineous families from remote areas of Sindh Province in Pakistan. This locus resides in an interval of approximately 7 cM on chromosome 15q23-q25.1.

AB - Nonsyndromic deafness locus (DFNB48) segregating as an autosomal recessive trait has been mapped to the long arm of chromosome 15 in bands q23-q25.1 in five large Pakistani families. The deafness phenotype in one of these five families (PKDF245) is linked to D15S1005 with a lod score of 8.6 at θ = 0, and there is a critical linkage interval of approximately 7 cM on the Marshfield human genetic map, bounded by microsatellite markers D15S216 (70.73 cM) and D15S1041 (77.69 cM). MYO9A, NR2E3, BBS4, and TMC3 are among the candidate genes in the DFNB48 region. The identification of another novel nonsyndromic recessive deafness locus demonstrates the high degree of locus heterogeneity for hearing impairment, particularly in the Pakistani population. Loci have been mapped either in endogamous population or in families with children of consanguineous marriages (Friedman and Griffith 2003). As a consequence of the unique socio-cultural practices in the population of Pakistan, aproximately 60% of marriages are consanquineous, of wich more than 80% are between first counsin (Hussain and Bittles 1998). These large consanguineous families are a powerful resource for genetic linkage studies of recessively inherited dis-order. In this communication, we report a novel deafness locus DFNB48 genetically mapped with the aid of five consanguineous families from remote areas of Sindh Province in Pakistan. This locus resides in an interval of approximately 7 cM on chromosome 15q23-q25.1.

UR - http://www.scopus.com/inward/record.url?scp=17144362873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17144362873&partnerID=8YFLogxK

U2 - 10.1007/s00439-004-1247-y

DO - 10.1007/s00439-004-1247-y

M3 - Article

C2 - 15711797

AN - SCOPUS:17144362873

VL - 116

SP - 407

EP - 412

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 5

ER -