Dextromethorphan protects male but not female mice with brain ischemia

Anne M. Comi; Bridget H. Highet; Paulomi Mehta; Tae Hana Chong; Michael V. Johnston; Mary Ann Wilson

doi:10.1097/01.wnr.0000220136.98918.41

Dextromethorphan protects male but not female mice with brain ischemia

Anne M. Comi, Bridget H. Highet, Paulomi Mehta, Tae Hana Chong, Michael V. Johnston, Mary Ann Wilson

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The non-competitive N-methyl-D-aspartate receptor antagonist dextromethorphan is protective against some types of brain injury. Unilateral carotid ligation in postnatal day 12 CD1 mice produces ischemic brain injury. To evaluate the neuroprotective potential of dextromethorphan against ischemic injury in the immature brain, seven litters of postnatal day 12 CD1 mice received either dextromethorphan or vehicle after a unilateral carotid ligation. Only the male pups were protected, and brain injury was unchanged in the female pups treated with dextromethorphan. These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent.

Original language	English (US)
Pages (from-to)	1319-1322
Number of pages	4
Journal	Neuroreport
Volume	17
Issue number	12
DOIs	https://doi.org/10.1097/01.wnr.0000220136.98918.41
State	Published - Aug 1 2006

Keywords

Carotid ligation
Dextromethorphan
Immature mouse
Ischemia
N-methyl-D-aspartate receptor
Sex-related neuroprotection

ASJC Scopus subject areas

General Neuroscience

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10.1097/01.wnr.0000220136.98918.41

Cite this

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title = "Dextromethorphan protects male but not female mice with brain ischemia",

abstract = "The non-competitive N-methyl-D-aspartate receptor antagonist dextromethorphan is protective against some types of brain injury. Unilateral carotid ligation in postnatal day 12 CD1 mice produces ischemic brain injury. To evaluate the neuroprotective potential of dextromethorphan against ischemic injury in the immature brain, seven litters of postnatal day 12 CD1 mice received either dextromethorphan or vehicle after a unilateral carotid ligation. Only the male pups were protected, and brain injury was unchanged in the female pups treated with dextromethorphan. These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent.",

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AU - Comi, Anne M.

AU - Highet, Bridget H.

AU - Mehta, Paulomi

AU - Hana Chong, Tae

AU - Johnston, Michael V.

AU - Ann Wilson, Mary

PY - 2006/8/1

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Dextromethorphan protects male but not female mice with brain ischemia

Abstract

Keywords

ASJC Scopus subject areas

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