Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity

Jiyoung Y. Cha, Hyo Jung Kim, Jung Hwan Yu, Jing Xu, Daham Kim, Bindu D. Paul, Hyeonjin Choi, Seyun Kim, Yoo Jeong Lee, Gary P. Ho, Feng Rao, Solomon H. Snyder, Jae Woo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Adipogenesis, the conversion of precursor cells into adipocytes, is associated with obesity and is mediated by glucocorticoids acting via hitherto poorly characterized mechanisms. Dexras1 is a small G protein of the Ras family discovered on the basis of its marked induction by the synthetic glucocorticoid dexamethasone. We show that Dexras1 mediates adipogenesis and diet-induced obesity. Adipogenic differentiation of 3T3-L1 cells is abolished with Dexras1 depletion, whereas overexpression of Dexras1 elicits adipogenesis. Adipogenesis is markedly reduced in mouse embryonic fibroblasts from Dexras1-deleted mice, whereas adiposity and dietinduced weight gain are diminished in the mutant mice.

Original languageEnglish (US)
Pages (from-to)20575-20580
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number51
DOIs
StatePublished - Dec 17 2013

Keywords

  • Cushing disease
  • Cyclic AMP
  • Insulin
  • Nitric oxide

ASJC Scopus subject areas

  • General

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