Dexfenfluramine-induced contraction of human and rat isolated pulmonary arteries

Larry A. Patnaude, Bradley J. Undem, Stephen T. O'Rourke

Research output: Contribution to journalArticlepeer-review

Abstract

Mechanisms of dexfenfluramine-induced vasoconstriction were studied in isolated pulmonary arteries suspended in organ baths for isometric tension recording. Dexfenfluramine (10-7-10-4 M) caused concentration-dependent contractions in rat and human pulmonary arteries with and without endothelium. In pulmonary arteries of the rat, the response to dexfenfluramine was nearly abolished by treatment with the α-adrenoceptor antagonists, phentolamine (10-6 M) or prazosin (10-7 M). In human pulmonary arteries, the concentration-response curve to dexfenfluramine was unaltered by the presence of phentolamine (10-6 M), prazosin (10-7 M), ketanserin (10-6 M), or indomethacin (3x10-6 M). The results suggest that dexfenfluramine causes contraction of pulmonary vascular smooth muscle by multiple mechanisms, one of which involves activation of α-adrenoceptors within the blood vessel wall. The mechanisms by which dexfenfluramine causes pulmonary vasoconstriction may differ between rat and human pulmonary arteries. Copyright (C) 2000.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalEuropean Journal of Pharmacology
Volume401
Issue number2
DOIs
StatePublished - Aug 4 2000

Keywords

  • Dexfenfluramine
  • Indomethacin
  • Ketanserin
  • Phentolamine
  • Prazosin
  • Pulmonary arteries

ASJC Scopus subject areas

  • Pharmacology

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