Abstract
An infusion device is described which permits sc infusion of methotrexate into mice at a constant rate. Physical characteristics of devices ranging in size from 0.27 mm internal diameter x 15 mm long to 1.95 mm internal diameter x 2 mm long are described. Plateau plasma concentrations of methotrexate (1 x 10-8M to 1 x 10-5M) achieved from infusion rates varying over three orders of magnitude (<1 - > 100 μg/hour) are presented. These data are evaluated in terms of the known toxic effects and pharmacokinetic behavior of this drug.
Original language | English (US) |
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Pages (from-to) | 889-893 |
Number of pages | 5 |
Journal | Cancer Treatment Reports |
Volume | 60 |
Issue number | 7 |
State | Published - 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research
- Oncology