Device for constant sc infusion of methotrexate: plasma results in mice

H. M. Pinedo, D. S. Zaharko, R. L. Dedrick

Research output: Contribution to journalArticlepeer-review

Abstract

An infusion device is described which permits sc infusion of methotrexate into mice at a constant rate. Physical characteristics of devices ranging in size from 0.27 mm internal diameter x 15 mm long to 1.95 mm internal diameter x 2 mm long are described. Plateau plasma concentrations of methotrexate (1 x 10-8M to 1 x 10-5M) achieved from infusion rates varying over three orders of magnitude (<1 - > 100 μg/hour) are presented. These data are evaluated in terms of the known toxic effects and pharmacokinetic behavior of this drug.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalCancer Treatment Reports
Volume60
Issue number7
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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