An infusion device is described which permits sc infusion of methotrexate into mice at a constant rate. Physical characteristics of devices ranging in size from 0.27 mm internal diameter x 15 mm long to 1.95 mm internal diameter x 2 mm long are described. Plateau plasma concentrations of methotrexate (1 x 10-8M to 1 x 10-5M) achieved from infusion rates varying over three orders of magnitude (<1 - > 100 μg/hour) are presented. These data are evaluated in terms of the known toxic effects and pharmacokinetic behavior of this drug.
|Original language||English (US)|
|Number of pages||5|
|Journal||Cancer Treatment Reports|
|State||Published - 1976|
ASJC Scopus subject areas
- Cancer Research