Developmental trajectories of the human embryologic brain regions

Kumiko Oishi, Jill Chotiyanonta, Dan Wu, Michael I. Miller, Susumu Mori, Kenichi Oishi

Research output: Contribution to journalArticle

Abstract

Vertebrate brains commonly consist of five basic embryologic anatomical regions: telencephalon; diencephalon; mesencephalon; metencephalon; and myelencephalon. The proportions of these regions vary widely across species and developmental stages. Investigation of their growth trajectories, therefore, has the potential to provide an understanding of the substrates of inter-species variation in neuroanatomy and function. To investigate the volumetric growth trajectories, structural magnetic resonance imaging (MRI) scans obtained from 618 healthy children (334 boys, 284 girls; ages 3–17 years old) were parcellated into five regions for the volume quantification. The sex- and region-specific growth trajectories were identified, and the most active growth was seen in the mesencephalon for both boys and girls. Whether similar regional growth patterns are seen in other species, or whether such patterns are related to evolution, are important questions that must be elucidated in the future.

Original languageEnglish (US)
Article number134342
JournalNeuroscience Letters
Volume708
DOIs
StatePublished - Aug 24 2019

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Brain
Growth
Mesencephalon
Myelencephalon
Metencephalon
Neuroanatomy
Diencephalon
Telencephalon
Vertebrates
Magnetic Resonance Imaging

Keywords

  • Atlas
  • Child
  • Diencephalon
  • Magnetic resonance imaging
  • Mesencephalon
  • Metencephalon
  • Myelencephalon
  • Telencephalon

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Developmental trajectories of the human embryologic brain regions. / Oishi, Kumiko; Chotiyanonta, Jill; Wu, Dan; Miller, Michael I.; Mori, Susumu; Oishi, Kenichi.

In: Neuroscience Letters, Vol. 708, 134342, 24.08.2019.

Research output: Contribution to journalArticle

Oishi, Kumiko ; Chotiyanonta, Jill ; Wu, Dan ; Miller, Michael I. ; Mori, Susumu ; Oishi, Kenichi. / Developmental trajectories of the human embryologic brain regions. In: Neuroscience Letters. 2019 ; Vol. 708.
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