Developmental regulation of cell migration: Insights from a genetic approach in Drosophila

Denise J. Montell

Research output: Contribution to journalArticlepeer-review

Abstract

Cell movements are fascinating and dramatic features of normal animal development. Moreover, failures in cell migration can lead to birth defects, and inappropriate cell migration can lead to cancer metastasis. Genetic approaches are beginning to provide some insights into the molecular basis for the developmental regulation of cell migration. This review discusses the progress that has been made in understanding the regulation of cell migration during Drosophila development, using a molecular genetic approach. In particular, these studies have implicated signaling through a receptor tyrosine kinase in the spatial control of migration. Reorganization of the cytoskeleton, under the control of the guanosine triphosphatase, Rac, is also critical for cell migration. Finally, genetic studies have demonstrated that the timing of cell migration is under transcriptional control.

Original languageEnglish (US)
Pages (from-to)219-229
Number of pages11
JournalCell Biochemistry and Biophysics
Volume31
Issue number3
DOIs
StatePublished - Jan 1 1999

Keywords

  • Adhesion
  • Cell migration
  • Genetics
  • Guidance receptors
  • Myosin
  • Rac GTPase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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