Developmental regression and autism reported to the Vaccine Adverse Event Reporting System

Emily Jane Woo, Robert Ball, Rebecca Landa, Andrew W. Zimmerman, M. Miles Braun, Marthe Bryant-Genevier, Dale R. Burwen, Soju Chang, Azra Dobardzic, Hector Izurieta, Ann W. McMahon, Phil Perucci, Lise Stevens, Scott Campbell, Penina Haber, John Iskander, Elaine Miller, Gina T. Mootrey, Vito Caserta

Research output: Contribution to journalArticlepeer-review


We report demographic and clinical characteristics of children reported to the US Vaccine Adverse Event Reporting System (VAERS) as having autism or another developmental disorder after vaccination. We completed 124 interviews with parents and reviewed medical records for 31 children whose records contained sufficient information to evaluate the child's developmental history. Medical record review indicated that 27 of 31 (87%) children had autism/ASD and 19 (61.3%) had evidence of developmental regression (loss of social, language, or motor skills). The proportion of VAERS cases of autism with regression was greater than that reported in population-based studies, based on the subset of VAERS cases with medical record confirmation. This difference may reflect preferential reporting to VAERS of autism with regression. In other respects, the children in this study appear to be similar to other children with autism. Further research might determine whether the pathogenesis of autism with developmental regression differs from that of autism without regression.

Original languageEnglish (US)
Pages (from-to)301-310
Number of pages10
Issue number4
StatePublished - Jul 2007


  • Adverse event
  • Autism
  • Regression
  • Vaccine

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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